Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 12/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016020 | 0.84 | ALDH1A1 (0.44) | ALDH1A1EGLN1TP53RAB9APARP1 | |
| SCHEMBL2718771 | 0.81 | KDM4E (0.50) | ALDH1A1EGLN1RAB9ANPC1KDM4E | |
| SCHEMBL2718191 | 0.79 | KDM4E (0.42) | ALDH1A1EGLN1TP53RAB9ARECQL | |
| SCHEMBL2017011 | 0.77 | TRPM8 (0.41) | ALDH1A1EGLN1PARP1L3MBTL1KDM4E | |
| SCHEMBL2011511 | 0.76 | KDM4E (0.40) | EGLN1TP53RAB9AMEN1NPC1 | |
| SCHEMBL15445450 | 0.75 | ALDH1A1 (0.69) | ALDH1A1EGLN1 | |
| SCHEMBL15445449 | 0.74 | ALDH1A1 (0.50) | ALDH1A1EGLN1TP53RAB9APARP1 | |
| SCHEMBL2721112 | 0.73 | ERN1 (0.43) | ALDH1A1EGLN1TP53RAB9AMEN1 | |
| SCHEMBL2016022 | 0.73 | CCR1 (0.39) | EGLN1TP53RAB9AMEN1NPC1 | |
| SCHEMBL2011836 | 0.71 | LMNA (0.40) | ALDH1A1TP53RAB9AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140031355-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2014-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031355-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, SSB, MALT1 | ALDH1A1 3702/4885EGLN1 2256/4885TP53 311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.