SCHEMBL15475864

SCHEMBL15475864

COc1cc(-n2cccn2)ccc1B1OC(C)(C)C(C)(C)O1

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 5/20 0.38
HCRTR2 O43614 5/20 0.38
NOTUM Q6P988 1/20 0.37
PTPN1 P18031 2/20 0.36
CCNT1 O60563 1/20 0.36
CDK9 P50750 1/20 0.36
NAMPT P43490 1/20 0.36
EGFR P00533 1/20 0.36
MAPT P10636 1/20 0.35
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 1/20 0.35
MAPK1 P28482 1/20 0.35
PDK2 Q15119 1/20 0.34
GHSR Q92847 1/20 0.34
KCNH2 Q12809 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29554552 1.00 HCRTR1 (0.38) HCRTR1HCRTR2NOTUMPTPN1CCNT1
SCHEMBL25167772 0.87 HCRTR1 (0.33) HCRTR1HCRTR2NOTUMCCNT1CDK9
SCHEMBL13310594 0.83 NOTUM (0.40) NOTUMNAMPTMAPTKDM4EALDH1A1
SCHEMBL26920637 0.83 NOTUM (0.46) NOTUMMAPTKDM4EALDH1A1MAPK1
SCHEMBL15056449 0.80 NOTUM (0.42) NOTUMMAPTKDM4EALDH1A1MAPK1
SCHEMBL15476487 0.79 EGFR (0.33) EGFRKCNH2
SCHEMBL15475890 0.78 EGFR (0.35) EGFRALDH1A1SMN1; SMN2
SCHEMBL23730216 0.78 CYP11B1 (0.48) HCRTR1HCRTR2NOTUMMAPTALDH1A1
SCHEMBL15876855 0.77 EGFR (0.34) EGFR
SCHEMBL27932708 0.76 NOTUM (0.49) HCRTR1HCRTR2NOTUMPTPN1CCNT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260028347-A1 HETEROCYCLIC AND HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS INC (US) 2026-01-29 US disclosed
EP-4434990-A1 HETEROCYCLIC AND HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE PTC Therapeutics, Inc. (US) 2024-09-25 EP disclosed
EP-3814357-B1 HETEROCYCLIC AND HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS INC (US) 2024-05-01 EP disclosed
US-20240132509-A1 HETEROCYCLIC AND HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS INC (US) 2024-04-25 US disclosed
US-11858941-B2 Heterocyclic and heteroaryl compounds for treating Huntington's disease PTC THERAPEUTICS, INC. (US) 2024-01-02 US disclosed
US-11858941-B2 Heterocyclic and heteroaryl compounds for treating Huntington's disease PTC THERAPEUTICS, INC. (US) 2024-01-02 US disclosed
US-11858941-B2 Heterocyclic and heteroaryl compounds for treating Huntington's disease PTC THERAPEUTICS, INC. (US) 2024-01-02 US disclosed
EP-4227304-A2 THIADIAZOLE ANALOGS AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH A DEFICIENCY OF SMN MOTOR NEURONS Novartis AG (CH) 2023-08-16 EP disclosed
EP-4227304-A2 THIADIAZOLE ANALOGS AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH A DEFICIENCY OF SMN MOTOR NEURONS Novartis AG (CH) 2023-08-16 EP disclosed
US-20230148184-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. 2023-05-11 US disclosed
US-9040712-B2 Thiadiazole analogs thereof and methods for treating SMN-deficiency-related-conditions NOVARTIS AG (CH) 2015-05-26 US disclosed
WO-2014116845-A1 THIADIAZOLE ANALOGS THEREOF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED-CONDITIONS NOVARTIS AG (CH) 2014-07-31 WO disclosed
WO-2014116845-A1 THIADIAZOLE ANALOGS THEREOF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED-CONDITIONS NOVARTIS AG (CH) 2014-07-31 WO disclosed
US-20140213570-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS AG (CH) 2014-07-31 US disclosed
US-20140206661-A1 THIADIAZOLE ANALOGS THEREOF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED-CONDITIONS NOVARTIS AG (CH) 2014-07-24 US disclosed
US-20140206661-A1 THIADIAZOLE ANALOGS THEREOF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED-CONDITIONS NOVARTIS AG (CH) 2014-07-24 US disclosed
US-20140206661-A1 THIADIAZOLE ANALOGS THEREOF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED-CONDITIONS NOVARTIS AG (CH) 2014-07-24 US disclosed
US-8729263-B2 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions NOVARTIS AG (CH) 2014-05-20 US disclosed
US-20140051672-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. 2014-02-20 US disclosed
WO-2014028459-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS AG (CH) 2014-02-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260028347-A1 HETEROCYCLIC AND HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE HTT, HYPK, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 HCRTR1 29/4885HCRTR2 68/4885NOTUM 3391/4885
US-11858941-B2 Heterocyclic and heteroaryl compounds for treating Huntington's disease HTT, HYPK, FH HCRTR1 233/4885HCRTR2 284/4885NOTUM 2627/4885
US-20140213570-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS SMN1; SMN2, CLN6, SF3B5 HCRTR1 4370/4885HCRTR2 4428/4885NOTUM 4490/4885
US-20140051672-A1 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS SMN1; SMN2, CLN6, SF3B5 HCRTR1 4370/4885HCRTR2 4428/4885NOTUM 4490/4885
US-20240132509-A1 HETEROCYCLIC AND HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE HTT, HCN3, TRPV1 HCRTR1 295/4885HCRTR2 191/4885NOTUM 4082/4885
US-20230148184-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING RBM17, SNRPA, SNRPA1 HCRTR1 4606/4885HCRTR2 4673/4885NOTUM 3680/4885
US-20140206661-A1 THIADIAZOLE ANALOGS THEREOF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED-CONDITIONS SMN1; SMN2, SF3B5, SF3B1 HCRTR1 4638/4885HCRTR2 4644/4885NOTUM 3645/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.