Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 6/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 3/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15499688 | 0.87 | ABCB1 (0.42) | MAOBABCB1MAOANR4A2 | |
| SCHEMBL15743872 | 0.85 | ABCB1 (0.44) | MAOBABCB1MAOAGHSRRAB9A | |
| SCHEMBL17794139 | 0.84 | CHRNB4 (0.43) | CHRNB4CHRNA3CHRNB2CHRNA4MAOB | |
| SCHEMBL15499685 | 0.81 | ABCB1 (0.47) | MAOBABCB1MAOA | |
| SCHEMBL17794171 | 0.81 | CHRNB4 (0.46) | CHRNB4CHRNA3CHRNB2CHRNA4MAOB | |
| SCHEMBL15743874 | 0.81 | ABCB1 (0.41) | MAOBABCB1MAOAGHSR | |
| SCHEMBL15499689 | 0.79 | F10 (0.41) | MAOBABCB1F10 | |
| SCHEMBL9239190 | 0.76 | CHRNB4 (0.60) | CHRNB4CHRNA3CHRNB2CHRNA4FAAH | |
| SCHEMBL9239198 | 0.76 | CHRNB4 (0.60) | CHRNB4CHRNA3CHRNB2CHRNA4FAAH | |
| SCHEMBL17794123 | 0.76 | SLC6A2 (0.45) | CHRNB4CHRNA3CHRNB2CHRNA4GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140066635-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NORTHWESTERN UNIVERSITY (US) | 2014-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140066635-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NOS2, NOS1, NOS3 | CHRNB4 82/4885CHRNA3 270/4885CHRNB2 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.