Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 16/20 | 0.40 |
| ▸ | MAOA | P21397 | 12/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15499686 | 0.87 | CHRNB4 (0.43) | ABCB1MAOBMAOANR4A2 | |
| SCHEMBL15743851 | 0.85 | NR1H2 (0.39) | — | |
| SCHEMBL15499685 | 0.84 | ABCB1 (0.47) | ABCB1MAOBMAOABDKRB2 | |
| SCHEMBL17794132 | 0.83 | NR1D1 (0.40) | — | |
| SCHEMBL15499689 | 0.81 | F10 (0.41) | ABCB1MAOB | |
| SCHEMBL17794170 | 0.80 | NR1H2 (0.40) | — | |
| SCHEMBL4325300 | 0.78 | ABCB1 (0.52) | ABCB1BDKRB2 | |
| SCHEMBL22324645 | 0.77 | ABCB1 (0.43) | ABCB1MAOBNR4A2 | |
| SCHEMBL15743874 | 0.77 | ABCB1 (0.41) | ABCB1MAOBMAOABDKRB2 | |
| SCHEMBL15499687 | 0.77 | ABCB1 (0.42) | ABCB1MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8735606-B2 | Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors | NORTHWESTERN UNIVERSITY (US) | 2014-05-27 | — | — | US | disclosed |
| US-20140066635-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NORTHWESTERN UNIVERSITY (US) | 2014-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140066635-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NOS2, NOS1, NOS3 | ABCB1 2151/4885MAOB 140/4885MAOA 125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.