Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 16/20 | 0.51 |
| ▸ | EPAS1 | Q99814 | 16/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29934508 | 0.67 | HIF1A (1.00) | HIF1AEPAS1 | |
| SCHEMBL7028753 | 0.66 | HIF1A (0.52) | HIF1AEPAS1ALDH1A1HTTFBP1 | |
| SCHEMBL13261732 | 0.65 | HIF1A (0.43) | HIF1AEPAS1ALDH1A1HTTFBP1 | |
| SCHEMBL29517025 | 0.62 | HIF1A (0.70) | HIF1AEPAS1FBP1MAPTMEN1 | |
| SCHEMBL5914907 | 0.61 | ALDH1A1 (0.53) | HIF1AEPAS1ALDH1A1HTTMAPT | |
| SCHEMBL5914896 | 0.60 | ALDH1A1 (0.52) | HIF1AEPAS1ALDH1A1HTTFBP1 | |
| SCHEMBL14220135 | 0.57 | ALDH1A1 (0.51) | HIF1AEPAS1ALDH1A1HTTMAPT | |
| SCHEMBL6628665 | 0.56 | CA9 (0.51) | HIF1AEPAS1ALDH1A1HTTMAPT | |
| SCHEMBL13016681 | 0.54 | ALDH1A1 (0.52) | HIF1AALDH1A1HTTMAPTMEN1 | |
| Rhodomyrtoxin B SCHEMBL12827333 | 0.54 | MAPT (1.00) | HIF1AEPAS1FBP1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2216335-B1 | TETRACYCLODIPYRANYL COUMARINS AND THE ANTI-HIV AND ANTI-TUBERCULOSIS USES THEREOF | INST MATERIA MEDICA CAMS (CN) | 2014-03-12 | — | — | EP | disclosed |