Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 9/20 | 0.52 |
| ▸ | EPAS1 | Q99814 | 8/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | FBP1 | P09467 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5914907 | 0.86 | ALDH1A1 (0.53) | HIF1AEPAS1ALDH1A1HTTKDM4E | |
| SCHEMBL5914896 | 0.85 | ALDH1A1 (0.52) | HIF1AEPAS1ALDH1A1HTTFBP1 | |
| SCHEMBL14220135 | 0.82 | ALDH1A1 (0.51) | HIF1AEPAS1ALDH1A1HTTKDM4E | |
| SCHEMBL7688550 | 0.80 | FFAR1 (0.47) | HIF1AEPAS1FBP1MEN1KMT2A | |
| SCHEMBL8926817 | 0.76 | ALDH1A1 (0.53) | HIF1AEPAS1ALDH1A1HTTKDM4E | |
| SCHEMBL13016681 | 0.72 | ALDH1A1 (0.52) | HIF1AALDH1A1HTTKDM4EGAA | |
| SCHEMBL6652101 | 0.70 | TSSK1B (0.48) | HIF1AEPAS1ALDH1A1HTTKDM4E | |
| SCHEMBL31152138 | 0.69 | ALDH1A1 (0.83) | ALDH1A1HTTKDM4EGAAMEN1 | |
| SCHEMBL3775925 | 0.69 | ALDH1A1 (0.83) | ALDH1A1HTTKDM4EGAAMEN1 | |
| SCHEMBL29934508 | 0.69 | HIF1A (1.00) | HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1143952-B1 | METHOD AND COMPOSITION FOR TREATING AND PREVENTING TUBERCULOSIS | SARAWAK MEDICHEM PHARMACEUTICALS INC (US) | 2003-02-26 | — | — | EP | disclosed |
| EP-1143952-A3 | METHOD AND COMPOSITION FOR TREATING AND PREVENTING TUBERCULOSIS | Sarawak Medichem Pharmaceuticals Inc. (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-1143952-A2 | METHOD AND COMPOSITION FOR TREATING AND PREVENTING TUBERCULOSIS | Sarawak Medichem Pharmaceuticals Inc. (US) | 2001-10-17 | — | — | EP | disclosed |
| US-20010027209-A1 | Method and composition for treating and preventing mycobacterium infections | SARAWAK MEDICHEM PHARMACEUTICALS, INC. | 2001-10-04 | — | — | US | disclosed |
| US-6277879-B1 | VIRICIDES | SARAWAK MEDICHEM PHARMACEUTICALS, INC. | 2001-08-21 | — | — | US | disclosed |
| US-6268393-B1 | CALANOLIDES AND ANALOGUES THEREOF | SARAWAK MEDICHEM PHARMACEUTICALS | 2001-07-31 | — | — | US | disclosed |
| WO-2000021514-A2 | METHOD AND COMPOSITION FOR TREATING AND PREVENTING TUBERCULOSIS | SARAWAK MEDICHEM PHARMACEUTICALS, INC. (US) | 2000-04-20 | — | — | WO | disclosed |
| US-5981770-A | HIV REVERSE TRANSCRIPTASE INHIBITOR, VIRICIDE | SARAWAK MEDICHEM PHARMACEUTICALS, INC. (US) | 1999-11-09 | — | — | US | disclosed |
| US-5977385-A | VIRICIDES | SARAWAK MEDICHEM PHARMACEUTICALS (US) | 1999-11-02 | — | — | US | disclosed |
| US-5892060-A | REVERSE TRANSCRIPTASE INHIBITOR; AIDS THERAPY | SARAWAK MEDICHEM PHARMACEUTICALS, INC. (US) | 1999-04-06 | — | — | US | disclosed |
| US-5872264-A | BENZO(1,2-B:5,6--B?)TRIPYRAN-2,12-DIONES | SARAWAK MEDICHEM PHARMACEUTICALS, INC. (US) | 1999-02-16 | — | — | US | disclosed |
| US-5859050-A | ADMINISTERING TO PREVENT OR TREAT A VIRAL INFECTION | SARAWAK MEDICHEM PHARMACEUTICALS, INC. (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1998038193-A1 | METHOD FOR THE PREPARATION OF (+)-CALANOLIDE A AND ANALOGUES THEREOF | MEDICHEM RESEARCH, INC. (US) | 1998-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010027209-A1 | Method and composition for treating and preventing mycobacterium infections | CYP51A1, DHCR7, CYP27A1 | HIF1A 3316/4885EPAS1 3673/4885ALDH1A1 2628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.