⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2702508 | 0.79 | — | — | |
| SCHEMBL105724 | 0.79 | — | — | |
| SCHEMBL271756 | 0.77 | — | — | |
| SCHEMBL4254942 | 0.77 | TAS1R3 (0.32) | — | |
| SCHEMBL269774 | 0.73 | — | — | |
| SCHEMBL20657646 | 0.73 | LMNA (0.40) | — | |
| SCHEMBL2700412 | 0.73 | KISS1R (0.32) | — | |
| SCHEMBL6762829 | 0.72 | KCNH3 (0.38) | — | |
| SCHEMBL271630 | 0.71 | ADH1B (0.50) | — | |
| SCHEMBL25179 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9187487-B2 | Azaindole derivatives as tyrosine kinase inhibitors | PRINCIPIA BIOPHARMA, INC. (US) | 2015-11-17 | — | — | US | claimed |
| US-20140073626-A1 | AZAINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | Principia Biopharma (US) | 2014-03-13 | — | — | US | claimed |
| US-9376438-B2 | Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors | PRINCIPIA BIOPHARMA, INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-9187487-B2 | Azaindole derivatives as tyrosine kinase inhibitors | PRINCIPIA BIOPHARMA, INC. (US) | 2015-11-17 | — | — | US | disclosed |
| US-20140221398-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PRINCIPIA BIOPHARMA INC. (US) | 2014-08-07 | — | — | US | disclosed |
| US-20140107151-A1 | TYROSINE KINASE INHIBITORS | Principia Biophama Inc. (US) | 2014-04-17 | — | — | US | disclosed |
| US-20140073626-A1 | AZAINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | Principia Biopharma (US) | 2014-03-13 | — | — | US | disclosed |