Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.49 |
| ▸ | CA1 | P00915 | 5/20 | 0.49 |
| ▸ | CA2 | P00918 | 5/20 | 0.49 |
| ▸ | CA3 | P07451 | 5/20 | 0.49 |
| ▸ | CA4 | P22748 | 5/20 | 0.49 |
| ▸ | CA6 | P23280 | 5/20 | 0.49 |
| ▸ | CA5A | P35218 | 5/20 | 0.49 |
| ▸ | CA7 | P43166 | 5/20 | 0.49 |
| ▸ | CA9 | Q16790 | 5/20 | 0.49 |
| ▸ | CA13 | Q8N1Q1 | 5/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.49 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15519416 | 0.83 | MAPK1 (0.54) | CA12CA1CA2CA3CA4 | |
| SCHEMBL15228510 | 0.82 | HTT (0.44) | CA2CA4ALDH1A1HTTNLRP3 | |
| SCHEMBL15229031 | 0.82 | HPGD (0.43) | CA12CA1CA2CA3CA4 | |
| SCHEMBL15228616 | 0.78 | F2R (0.42) | ALDH1A1HTTNLRP3HPGDHDAC3 | |
| SCHEMBL12260924 | 0.77 | MMP2 (0.55) | ALDH1A1HTTHPGDMAPTKDM4E | |
| SCHEMBL8894839 | 0.77 | ALDH1A1 (0.62) | ALDH1A1HTTNLRP3MAPTKDM4E | |
| SCHEMBL2062590 | 0.76 | PLK1 (0.49) | ALDH1A1HPGDRAB9AGAA | |
| SCHEMBL1204120 | 0.76 | ALDH1A1 (0.62) | ALDH1A1HTTHPGDMAPTKDM4E | |
| SCHEMBL27649297 | 0.76 | CTSD (0.51) | ALDH1A1HTTHPGDMAPTRAB9A | |
| SCHEMBL28012529 | 0.75 | NLRP3 (0.60) | ALDH1A1HTTNLRP3HPGDHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2708540-B1 | PYRIMIDO-DIAZEPINONE COMPOUND | KYOWA HAKKO KIRIN CO LTD (JP) | 2018-07-25 | — | — | EP | disclosed |
| US-9453021-B2 | Pyrimidodiazepinone compound | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2016-09-27 | — | — | US | disclosed |
| US-20140171422-A1 | PYRIMIDODIAZEPINONE COMPOUND | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2014-06-19 | — | — | US | disclosed |
| EP-2708540-A1 | PYRIMIDO-DIAZEPINONE COMPOUND | Kyowa Hakko Kirin Co., Ltd. (JP) | 2014-03-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140171422-A1 | PYRIMIDODIAZEPINONE COMPOUND | REN, AGTR1, KCNJ1 | CA12 4143/4885CA1 3012/4885CA2 1730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.