Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | OAT | P04181 | 1/20 | 0.34 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20450103 | 0.77 | OAT (0.33) | OAT | |
| SCHEMBL6810992 | 0.70 | DHODH (0.43) | — | |
| SCHEMBL18864186 | 0.69 | — | — | |
| SCHEMBL5474955 | 0.68 | KDM4E (0.39) | GAAHSD17B10OAT | |
| SCHEMBL12491709 | 0.67 | DHODH (0.41) | — | |
| SCHEMBL217840 | 0.67 | DHODH (0.41) | — | |
| SCHEMBL252263 | 0.67 | DHODH (0.45) | — | |
| SCHEMBL17024326 | 0.67 | DHODH (0.41) | — | |
| SCHEMBL17024327 | 0.67 | DHODH (0.41) | — | |
| SCHEMBL12491707 | 0.67 | DHODH (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116875641-A | Feeding method for improving fermentation yield of rapamycin | 丽珠集团福州福兴医药有限公司 | 2023-10-13 | — | — | CN | disclosed |
| US-9605001-B2 | Production of polyketides and other natural products | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2017-03-28 | — | — | US | disclosed |
| US-20150266896-A1 | PRODUCTION OF POLYKETIDES AND OTHER NATURAL PRODUCTS | BIOTICA TECH LTD (GB) | 2015-09-24 | — | — | US | disclosed |
| EP-1521828-B1 | PRODUCTION OF POLYKETIDES | BUCK INST FOR RES ON AGING (US) | 2015-07-01 | — | — | EP | disclosed |
| US-9040259-B2 | Production of polyketides and other natural products | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2015-05-26 | — | — | US | disclosed |
| US-20110165633-A1 | Production of Polyketides and Other Natural Products | BUCK INSTITUTE FOR RESEARCH ON AGING | 2011-07-07 | — | — | US | disclosed |
| EP-2313419-A1 | NOVEL COMPOUNDS AND METHODS FOR THEIR PRODUCTION | Biotica Technology Limited (GB) | 2011-04-27 | — | — | EP | disclosed |
| WO-2010106366-A1 | FK506 AND FK520 ANALOGUES AND THEIR PHARMACEUTICAL USES | BIOTICA TECHNOLOGY LIMITED (GB) | 2010-09-23 | — | — | WO | disclosed |
| US-7714118-B2 | recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide; for immunosuppression or to stimulate nerve growth and regeneration | KOSAN BIOSCIENCES INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| WO-2010004304-A1 | NOVEL COMPOUNDS AND METHODS FOR THEIR PRODUCTION | BIOTICA TECHNOLOGY LIMITED (GB) | 2010-01-14 | — | — | WO | disclosed |
| US-6759536-B2 | GENETIC ENGINEERING; POLYKETIDES | KOSAN BIOSCIENCES, INC. | 2004-07-06 | — | — | US | disclosed |
| WO-2004007709-A2 | PRODUCTION OF POLYKETIDES | BIOTICA TECHNOLOGY LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |
| US-6670168-B1 | Cell comprises a modified rapamycin polyketide synthase (PKS) gene cluster with an acyltransferase (AT) domain in extender module 10 having malonyl CoA specificity. | KOSAN BIOSCIENCE, INC. | 2003-12-30 | — | — | US | disclosed |
| US-6660862-B2 | Genetic engineering | KOSAN BIOSCIENCES, INC. | 2003-12-09 | — | — | US | disclosed |
| US-20030175901-A1 | Genetic engineering; polyketides | REEVES CHRISTOPHER (US) | 2003-09-18 | — | — | US | disclosed |
| US-6503737-B1 | Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase | KOSAN BIOSCIENCES, INC. | 2003-01-07 | — | — | US | disclosed |
| US-20020010328-A1 | Genetic engineering | REEVES CHRISTOPHER (US) | 2002-01-24 | — | — | US | disclosed |
| EP-1117801-A2 | POLYKETIDE SYNTHASE ENZYMES AND RECOMBINANT DNA CONSTRUCTS THEREFOR | Kosan Biosciences, Inc. (US) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000020601-A9 | POLYKETIDE SYNTHASE ENZYMES AND RECOMBINANT DNA CONSTRUCTS THEREFOR | KOSAN BIOSCIENCES INC (US) | 2000-08-31 | — | — | WO | disclosed |
| WO-2000020601-A2 | POLYKETIDE SYNTHASE ENZYMES AND RECOMBINANT DNA CONSTRUCTS THEREFOR | KOSAN BIOSCIENCES, INC. (US) | 2000-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266896-A1 | PRODUCTION OF POLYKETIDES AND OTHER NATURAL PRODUCTS | FKBP14, FKBP4, FKBP2 | GAA 668/4885HSD17B10 547/4885OAT 3825/4885 |
| US-20020010328-A1 | Genetic engineering | FDPS, DTYMK, COASY | GAA 84/4885HSD17B10 206/4885OAT 1707/4885 |
| US-20030175901-A1 | Genetic engineering; polyketides | FDPS, PFAS, COASY | GAA 107/4885HSD17B10 167/4885OAT 1586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.