Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 6/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.32 |
| ▸ | PNMT | P11086 | 3/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 2/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15524903 | 0.87 | RORC (0.32) | RORCNR1H2NR1H3PPARGNR1I2 | |
| SCHEMBL6192228 | 0.72 | PNMT (0.50) | PNMTADRA2AMTNR1A | |
| SCHEMBL7691593 | 0.70 | POLB (0.37) | SLC6A4 | |
| SCHEMBL6192806 | 0.70 | PNMT (0.37) | PNMTADRA2AMTNR1ASLC6A4 | |
| SCHEMBL11472931 | 0.70 | AR (0.42) | RORCNR1H2NR1H3NR1I2AR | |
| SCHEMBL16553844 | 0.68 | RORC (0.49) | RORCNR1H2NR1H3 | |
| SCHEMBL6754201 | 0.68 | AR (0.38) | PNMTAR | |
| SCHEMBL6754202 | 0.68 | AR (0.38) | PNMTAR | |
| SCHEMBL3625724 | 0.68 | GAA (0.42) | RORCNR1H2NR1H3NR1I2AR | |
| SCHEMBL15528373 | 0.67 | HDAC6 (0.54) | RORCNR1H3AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2844260-A1 | ROR MODULATORS AND THEIR USES | Gaweco, Anderson (US) | 2015-03-11 | — | — | EP | disclosed |
| WO-2013166015-A1 | ROR MODULATORS AND THEIR USES | GAWECO ANDERSON (US) | 2013-11-07 | — | — | WO | disclosed |