Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 15/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19240980 | 0.82 | GLA (0.40) | RORCGLATSHR | |
| SCHEMBL16553618 | 0.81 | MTNR1A (0.49) | GLATSHR | |
| SCHEMBL21787545 | 0.72 | RORC (0.55) | RORCNR1H3 | |
| SCHEMBL18197189 | 0.72 | NOD2 (0.35) | RORC | |
| SCHEMBL14822091 | 0.72 | GLA (0.55) | GLATSHR | |
| SCHEMBL18896616 | 0.72 | RORC (0.87) | RORC | |
| SCHEMBL18896617 | 0.72 | RORC (0.87) | RORC | |
| SCHEMBL16553718 | 0.72 | RORC (0.87) | RORC | |
| SCHEMBL16564686 | 0.69 | GAA (0.46) | RORCNR1H2NR1H3 | |
| SCHEMBL11472931 | 0.69 | AR (0.42) | RORCTSHRNR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3046906-B1 | ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2017-08-16 | — | — | EP | disclosed |
| EP-3046906-B1 | ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2017-08-16 | — | — | EP | disclosed |
| US-9725443-B2 | RORγ modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-08-08 | — | — | US | disclosed |
| US-9725443-B2 | RORγ modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-08-08 | — | — | US | disclosed |
| US-9663469-B2 | RORγ modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-05-30 | — | — | US | disclosed |
| US-9663469-B2 | RORγ modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-05-30 | — | — | US | disclosed |
| US-20160318870-A1 | RORy MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-11-03 | — | — | US | disclosed |
| US-20160229844-A1 | RORgamma MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-08-11 | — | — | US | disclosed |
| EP-3046906-A1 | ROR MODULATORS | Bristol-Myers Squibb Company (US) | 2016-07-27 | — | — | EP | disclosed |
| EP-3044219-A1 | RORGAMMA MODULATORS | Bristol-Myers Squibb Company (US) | 2016-07-20 | — | — | EP | disclosed |
| WO-2015042212-A1 | RORγ MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-03-26 | — | — | WO | disclosed |
| WO-2015035278-A1 | RORγ MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-03-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318870-A1 | RORy MODULATORS | RORB, RORC, RORA | RORC 2/4885GLA 1584/4885TSHR 417/4885 |
| US-20160229844-A1 | RORgamma MODULATORS | RORB, RORC, RORA | RORC 2/4885GLA 1397/4885TSHR 516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.