Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15535650 | 0.89 | RAB9A (0.46) | SMN1; SMN2PKMRAB9APOLBTSHR | |
| SCHEMBL19267071 | 0.80 | POLB (0.54) | SMN1; SMN2POLBTSHRALDH1A1LMNA | |
| SCHEMBL15535476 | 0.80 | P2RX3 (0.44) | SMN1; SMN2PKMRAB9AALDH1A1MEN1 | |
| SCHEMBL3420439 | 0.78 | EGLN3 (0.64) | SMN1; SMN2POLBTSHRALDH1A1LMNA | |
| SCHEMBL15536589 | 0.74 | NPSR1 (0.41) | SMN1; SMN2PKMRAB9APOLBTSHR | |
| SCHEMBL3419511 | 0.74 | EGLN3 (0.62) | SMN1; SMN2PKMPOLBTSHRALDH1A1 | |
| SCHEMBL15535643 | 0.72 | ALDH1A1 (0.37) | SMN1; SMN2TSHRALDH1A1LMNAMAPT | |
| SCHEMBL3977468 | 0.71 | SMN1; SMN2 (0.48) | SMN1; SMN2PKMRAB9APOLBALDH1A1 | |
| SCHEMBL3419394 | 0.71 | EGLN3 (0.66) | SMN1; SMN2PKMRAB9APOLBALDH1A1 | |
| SCHEMBL7128852 | 0.70 | PDE4A (0.42) | SMN1; SMN2RAB9APOLBTSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013177478-A2 | TREATMENT METHOD | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2013-11-28 | — | — | WO | disclosed |