SCHEMBL15539482

SCHEMBL15539482

COC(=O)c1cnc(-c2ccc(Oc3ccccc3)cc2F)cn1

nearest known ligand 0.46

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 1/20 0.46
FEN1 P39748 7/20 0.45
XDH P47989 1/20 0.41
ALOX5AP P20292 5/20 0.40
FAAH O00519 2/20 0.40
HPGDS O60760 1/20 0.40
GRM2 Q14416 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
ALPL P05186 1/20 0.39
FFAR1 O14842 1/20 0.38
FFAR4 Q5NUL3 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15539481 0.85 P4HTM (0.46) FEN1FAAHFFAR1
SCHEMBL15539723 0.80 GABRP (0.46) FEN1ALOX5APALPL
SCHEMBL15539943 0.75 TDP1 (0.43) FEN1TDP1
Hydrochloric Acid SCHEMBL15538309 0.74 TDP1 (0.45) FEN1TDP1
SCHEMBL28674760 0.74 ABL1 (0.55) XDHFAAHTDP1
SCHEMBL23386692 0.73 XDH (0.51) XDHFAAHTDP1
SCHEMBL21906505 0.73 TDP1 (0.49) HPGDSTDP1
SCHEMBL931505 0.73 OXTR (0.59) FEN1ALOX5APALPL
SCHEMBL25213243 0.72 MEN1 (0.49) TDP1
SCHEMBL31444286 0.72 OXTR (0.46)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2858986-B1 PIPERIDINE DERIVATIVES AS GPR119 AGONISTS CHONG KUN DANG PHARMACEUTICAL CORP (KR) 2019-10-30 EP disclosed
US-9944600-B2 Piperidine derivatives for GPR119 agonist CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2018-04-17 US disclosed
US-20150166480-A1 PIPERIDINE DERIVATIVES FOR GPR119 AGONIST CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2015-06-18 US disclosed
EP-2858986-A1 PIPERIDINE DERIVATIVES FOR GPR119 AGONIST Chong Kun Dang Pharmaceutical Corp. (KR) 2015-04-15 EP disclosed
WO-2013187646-A1 PIPERIDINE DERIVATIVES FOR GPR119 AGONIST CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2013-12-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150166480-A1 PIPERIDINE DERIVATIVES FOR GPR119 AGONIST GPR119, FFAR2, GPR84 SCN9A 746/4885FEN1 4874/4885XDH 4342/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.