Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GHSR | Q92847 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15543800 | 0.94 | GPR183 (0.46) | GPR183NPC1HPGDRAB9AGHSR | |
| SCHEMBL15543665 | 0.86 | FKBP1A (0.47) | RAB9AGHSRALDH1A1POLBGAA | |
| SCHEMBL15543111 | 0.86 | GHSR (0.52) | GHSRALDH1A1POLBSMN1; SMN2MEN1 | |
| SCHEMBL15543282 | 0.84 | MDH1 (0.45) | GHSRALDH1A1LMNAMAPTUSP2 | |
| SCHEMBL15543553 | 0.81 | GPR183 (0.46) | GPR183NPC1HPGDRAB9AGHSR | |
| SCHEMBL16468384 | 0.80 | NPC1 (0.47) | GPR183NPC1HPGDRAB9AGHSR | |
| SCHEMBL15542733 | 0.80 | NPC1 (0.47) | GPR183NPC1HPGDRAB9AGHSR | |
| SCHEMBL15542805 | 0.78 | RAB9A (0.34) | RAB9A | |
| SCHEMBL15543143 | 0.77 | NPC1 (0.44) | GPR183NPC1HPGDRAB9AGHSR | |
| SCHEMBL15543144 | 0.77 | NPC1 (0.44) | GPR183NPC1HPGDRAB9AGHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864309-A1 | COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER DISEASES | Cadila Healthcare Limited (IN) | 2015-04-29 | — | — | EP | disclosed |
| WO-2014002105-A1 | COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER DISEASES | CADILA HEALTHCARE LIMITED (IN) | 2014-01-03 | — | — | WO | disclosed |