Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 5/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30421685 | 1.00 | CES1 (0.41) | CES1HTR2CABHD6TRPA1CARM1 | |
| SCHEMBL22989998 | 0.82 | TRPA1 (0.34) | HTR2CABHD6TRPA1CARM1PRMT6 | |
| SCHEMBL14123611 | 0.82 | ABHD6 (0.34) | ABHD6TRPA1CARM1PRMT6PRMT1 | |
| SCHEMBL12229339 | 0.82 | ABHD6 (0.32) | HTR2CABHD6TRPA1CARM1PRMT6 | |
| SCHEMBL30842183 | 0.79 | SIGMAR1 (0.35) | ABHD6TRPA1CARM1PRMT6PRMT1 | |
| SCHEMBL15829226 | 0.78 | CD44 (0.44) | CES1HTR2CADRA2A | |
| SCHEMBL21936820 | 0.78 | ABHD6 (0.33) | ABHD6TRPA1CARM1PRMT6PRMT1 | |
| SCHEMBL11960180 | 0.78 | BCL2L1 (0.50) | CES1HTR2C | |
| SCHEMBL30842146 | 0.76 | SIGMAR1 (0.33) | ABHD6TRPA1CARM1PRMT6PRMT1 | |
| SCHEMBL7917850 | 0.75 | CARM1 (0.32) | ABHD6CARM1PRMT6PRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116194456-A | Preparation of heterocyclic compounds as KRAS inhibitors and methods of use thereof | 上海科州药物研发有限公司 | 2023-05-30 | — | — | CN | disclosed |
| WO-2021219072-A1 | PREPARATION AND APPLICATION METHOD OF HETEROCYCLIC COMPOUND AS KRAS INHIBITOR | 上海科州药物研发有限公司 (CN) | 2021-11-04 | — | — | WO | disclosed |
| US-9688608-B2 | Pyrazole tetrahydronaphthyl carboxamides | BAYER CROPSCIENCE AG (DE) | 2017-06-27 | — | — | US | disclosed |
| US-9630943-B2 | Tetrahydronaphthyl(thio) carboxamides | BAYER CROPSCIENCE AG (DE) | 2017-04-25 | — | — | US | disclosed |
| US-9428459-B2 | Difluoromethyl-nicotinic- tetrahydronaphtyl carboxamides | BAYER CROPSCIENCE AG (DE) | 2016-08-30 | — | — | US | disclosed |
| US-20160039741-A1 | PYRAZOLE TETRAHYDRONAPHTHYL CARBOXAMIDES | BAYER CROPSCIENCE AG (DE) | 2016-02-11 | — | — | US | disclosed |
| US-9204646-B2 | Pyrazole tetrahydronaphthyl carboxamides | BAYER CROPSCIENCE AG (DE) | 2015-12-08 | — | — | US | disclosed |
| US-20150329517-A1 | TETRAHYDRONAPHTHYL(THIO) CARBOXAMIDES | BAYER CROPSCIENCE AG (DE) | 2015-11-19 | — | — | US | disclosed |
| US-20150322013-A1 | DIFLUOROMETHYL-NICOTINIC- TETRAHYDRONAPHTYL CARBOXAMIDES | BAYER CROPSCIENCE AG (US) | 2015-11-12 | — | — | US | disclosed |
| EP-2935218-A1 | DIFLUOROMETHYL-NICOTINIC- TETRAHYDRONAPHTYL CARBOXAMIDES | Bayer CropScience AG (DE) | 2015-10-28 | — | — | EP | disclosed |
| EP-2935223-A1 | TETRAHYDRONAPHTHYL(THIO) CARBOXAMIDES | Bayer CropScience AG (DE) | 2015-10-28 | — | — | EP | disclosed |
| EP-2877456-A1 | PYRAZOLE TETRAHYDRONAPHTHYL CARBOXAMIDES | Bayer CropScience AG (DE) | 2015-06-03 | — | — | EP | disclosed |
| US-20150119242-A1 | PYRAZOLE TETRAHYDRONAPHTHYL CARBOXAMIDES | BAYER CROPSCIENCE AG (DE) | 2015-04-30 | — | — | US | disclosed |
| WO-2014095678-A1 | TETRAHYDRONAPHTHYL(THIO) CARBOXAMIDES | BAYER CROPSCIENCE AG (DE) | 2014-06-26 | — | — | WO | disclosed |
| WO-2014095677-A1 | DIFLUOROMETHYL-NICOTINIC- TETRAHYDRONAPHTYL CARBOXAMIDES | BAYER CROPSCIENCE AG (DE) | 2014-06-26 | — | — | WO | disclosed |
| WO-2013167548-A1 | PYRAZOLE TETRAHYDRONAPHTHYL CARBOXAMIDES | BAYER CROPSCIENCE AG (DE) | 2013-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150322013-A1 | DIFLUOROMETHYL-NICOTINIC- TETRAHYDRONAPHTYL CARBOXAMIDES | NAPRT, NNMT, NAMPT | CES1 1159/4885HTR2C 995/4885ABHD6 1522/4885 |
| US-20160039741-A1 | PYRAZOLE TETRAHYDRONAPHTHYL CARBOXAMIDES | TPMT, HDHD5, CBR3 | CES1 1172/4885HTR2C 2356/4885ABHD6 2726/4885 |
| US-20150119242-A1 | PYRAZOLE TETRAHYDRONAPHTHYL CARBOXAMIDES | TPMT, HDHD5, CBR3 | CES1 1172/4885HTR2C 2356/4885ABHD6 2726/4885 |
| US-20150329517-A1 | TETRAHYDRONAPHTHYL(THIO) CARBOXAMIDES | HDHD5, TPMT, TIAL1 | CES1 1294/4885HTR2C 2092/4885ABHD6 872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.