SCHEMBL15592424

SCHEMBL15592424

COc1ccc(C(OC[C@@H]2C[C@@H](O)CN2C(=O)C(F)(F)F)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SLC6A11 P48066 8/20 0.45
SLC6A1 P30531 3/20 0.45
SLC6A12 P48065 2/20 0.40
TP53 P04637 2/20 0.40
MEN1 O00255 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
KMT2A Q03164 1/20 0.40
SLC6A13 Q9NSD5 1/20 0.40
TYMP P19971 1/20 0.39
KIF11 P52732 1/20 0.37
RIPK1 Q13546 1/20 0.37
ALDH1A1 P00352 2/20 0.36
LMNA P02545 2/20 0.36
MAPT P10636 2/20 0.36
KDM4E B2RXH2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19463293 0.91 SLC6A11 (0.46) SLC6A11SLC6A1SLC6A12TP53MEN1
SCHEMBL3088920 0.89 SLC6A11 (0.48) SLC6A11SLC6A1SLC6A12TP53MEN1
SCHEMBL9908646 0.89 SLC6A11 (0.47) SLC6A11SLC6A1SLC6A12TP53MEN1
SCHEMBL8662709 0.86 MTNR1B (0.37) SLC6A11SLC6A1TP53MEN1KMT2A
SCHEMBL16248722 0.85 SLC6A11 (0.44) SLC6A11SLC6A1SLC6A12TP53MEN1
SCHEMBL8662717 0.84 MTNR1B (0.37) SLC6A1SLC6A12TP53MEN1KMT2A
SCHEMBL12248426 0.83 POLB (0.46) SLC6A11SLC6A1SLC6A12TP53MEN1
SCHEMBL764125 0.82 SLC6A11 (0.52) SLC6A11SLC6A1SLC6A12TP53MEN1
SCHEMBL24383294 0.82 SLC6A11 (0.42) SLC6A11SLC6A1SLC6A12TP53MEN1
SCHEMBL9604514 0.82 SLC6A11 (0.42) SLC6A11SLC6A1SLC6A12TP53MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150196655-A1 CARBOHYDRATE CONJUGATED RNA AGENTS AND PROCESS FOR THEIR PREPARATION BANK OF AMERICA, N.A. 2015-07-16 US disclosed
US-20150196655-A1 CARBOHYDRATE CONJUGATED RNA AGENTS AND PROCESS FOR THEIR PREPARATION BANK OF AMERICA, N.A. 2015-07-16 US disclosed
WO-2014025805-A1 CARBOHYDRATE CONJUGATED RNA AGENTS AND PROCESS FOR THEIR PREPARATION ALNYLAM PHARMACEUTICALS, INC. (US) 2014-02-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150196655-A1 CARBOHYDRATE CONJUGATED RNA AGENTS AND PROCESS FOR THEIR PREPARATION RNASE1, IGF2BP1, IGF2BP2 SLC6A11 4095/4885SLC6A1 4277/4885SLC6A12 3238/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.