Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CTSH | P09668 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28276972 | 0.78 | ALDH1A1 (0.53) | ALDH1A1CTSBCTSHTDP1MAPT | |
| SCHEMBL20838472 | 0.78 | MAPT (0.55) | ALDH1A1CTSBCTSHMAPTGAA | |
| SCHEMBL6594784 | 0.76 | ALDH1A1 (0.51) | ALDH1A1CTSBCTSHTDP1MAPT | |
| SCHEMBL6599574 | 0.76 | ALDH1A1 (0.51) | ALDH1A1CTSBCTSHTDP1MAPT | |
| SCHEMBL1562000 | 0.75 | CTSB (0.62) | ALDH1A1CTSBCTSHTDP1MAPT | |
| SCHEMBL878950 | 0.72 | OPRK1 (0.52) | ALDH1A1TDP1MAPTGAALMNA | |
| SCHEMBL10700281 | 0.72 | CTSB (0.55) | ALDH1A1CTSBCTSHTDP1MAPT | |
| SCHEMBL28052114 | 0.72 | ALDH1A1 (0.45) | ALDH1A1CTSBCTSHTDP1MAPT | |
| SCHEMBL1225832 | 0.71 | ALDH1A1 (1.00) | ALDH1A1CTSBCTSHTDP1MAPT | |
| SCHEMBL8548121 | 0.70 | CTSB (0.60) | ALDH1A1CTSBCTSHMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2353593-B1 | Non-nucleoside reverse transcriptase inhibitors | ARDEA BIOSCIENCES INC (US) | 2012-08-22 | — | — | EP | disclosed |
| EP-2353593-A1 | Non-nucleoside reverse transcriptase inhibitors | Ardea Biosciences, Inc. (US) | 2011-08-10 | — | — | EP | disclosed |
| EP-1545483-B1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | ARDEA BIOSCIENCES INC (US) | 2011-04-06 | — | — | EP | disclosed |
| CN-1697650-B | Non-nucleoside reverse transcriptase inhibitors | ARDEA BIOSCIENCES INC | 2010-11-10 | — | — | CN | disclosed |
| EP-1545483-A4 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | ARDEA BIOSCIENCES INC (US) | 2009-03-25 | — | — | EP | disclosed |
| US-20080249131-A1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | ARDEA BIOSCIENCES, INC. (US) | 2008-10-09 | — | — | US | disclosed |
| US-20060135556-A1 | Non-nucleoside reverse transcriptase inhibitors | INTRABIOTICS PHARMACEUTICALS, INC. | 2006-06-22 | — | — | US | disclosed |
| CN-1697650-A | Non-nucleoside reverse transcriptase inhibitors | RIBAPHARM INC (US) | 2005-11-16 | — | — | CN | disclosed |
| EP-1545483-A2 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | Ribapharm Inc. (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004030611-A2 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | RIBAPHARM INC. (US) | 2004-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249131-A1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | POLRMT, TYMP, RNGTT | ALDH1A1 271/4885CTSB 1190/4885CTSH 1221/4885 |
| US-20060135556-A1 | Non-nucleoside reverse transcriptase inhibitors | POLRMT, TYMP, RNGTT | ALDH1A1 271/4885CTSB 1190/4885CTSH 1221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.