Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9121840 | 1.00 | TAAR1 (0.44) | TAAR1CYP2D6CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL9817490 | 1.00 | TAAR1 (0.44) | TAAR1CYP2D6CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL9121020 | 0.80 | CYP2D6 (0.42) | TAAR1CYP2D6CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL29457704 | 0.76 | CYP2D6 (0.63) | TAAR1CYP2D6CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL10346211 | 0.73 | TAAR1 (0.47) | TAAR1CYP2D6CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL3640366 | 0.72 | TAAR1 (0.50) | TAAR1CYP2D6CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL29038820 | 0.72 | CYP2C19 (0.49) | TAAR1CYP2D6CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL41959 | 0.70 | ALDH1A1 (0.50) | TAAR1CYP2C19ALDH1A1LMNACYP1A2 | |
| Hydrogen Peroxide SCHEMBL27577220 | 0.70 | ALDH1A1 (0.55) | TAAR1CYP2C19ALDH1A1LMNACYP1A2 | |
| SCHEMBL10514033 | 0.69 | SMN1; SMN2 (0.43) | TAAR1CYP2D6CYP2C19ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8653134-B2 | Hydroxyphenol derivatives, processes for the preparation thereof, pharmaceutical compositions them, and therapeutic uses thereof | MERCK PATENT GMBH (DE) | 2014-02-18 | — | — | US | disclosed |
| EP-1836149-B1 | PHENYLBENZOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC USES THEREOF | MERCK PATENT GMBH (DE) | 2011-04-06 | — | — | EP | disclosed |
| US-7863328-B2 | Phenylbenzoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic uses thereof | MERCK PATENT GMBH (DE) | 2011-01-04 | — | — | US | disclosed |
| US-20080194608-A1 | 6-Phenylhex-5-Enoic Acid Derivatives, Process for the Preparation Thereof, Pharmaceutical Compositions Comprising Them, and Therapeutic Uses Thereof | MERCK PATENT GMBH (DE) | 2008-08-14 | — | — | US | disclosed |
| US-20080161308-A1 | e.g. 4-[6-(2-cyclohexylethoxy)-3-oxoindan-5-yloxy]butanoic acid; peroxisome proliferator-activated receptor (PPAR) gamma agonist; antiinflammatory, antidiabetic agent; dyslipidaemia, atherosclerosis, insulin resistance | MERCK PATENT GMBH (DE) | 2008-07-03 | — | — | US | disclosed |
| US-20080139599-A1 | Phenylbenzoic Acid Derivatives, Processes for the Preparation Thereof, Pharmaceutical Compositions Comprising Them, and Therapeutic Uses Thereof | MERCK PATENT GMBH (DE) | 2008-06-12 | — | — | US | disclosed |
| EP-1838655-A1 | 6-PHENYLHEX-5-ENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC USES THEREOF | Merck Patent GmbH (DE) | 2007-10-03 | — | — | EP | disclosed |
| EP-1836150-A1 | HYDROXYPHENOL DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC USES THEREOF | Merck Patent GmbH (DE) | 2007-09-26 | — | — | EP | disclosed |
| EP-1836149-A1 | PHENYLBENZOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC USES THEREOF | Merck Patent GmbH (DE) | 2007-09-26 | — | — | EP | disclosed |
| EP-1836187-A1 | 1H-INDOLE-3-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PPAR AGONISTS | Merck Patent GmbH (DE) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006074797-A1 | 6-PHENYLHEX-5-ENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC USES THEREOF | MERCK PATENT GMBH (DE) | 2006-07-20 | — | — | WO | disclosed |
| WO-2006074798-A1 | HYDROXYPHENOL DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC USES THEREOF | MERCK PATENT GMBH (DE) | 2006-07-20 | — | — | WO | disclosed |
| WO-2006011045-A1 | PHOTORACEMIZATION OF 2-TRIFLUOROMETHYL-2H-CHROMENE-3-CARBOXYLIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY LLC (US) | 2006-02-02 | — | — | WO | disclosed |
| WO-2006011052-A1 | METHOD FOR THE RACEMIZATION OF 2-TRIFLUORO-2H-CHROMENE-3-CARBOXYLIC ACIDS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-02-02 | — | — | WO | disclosed |
| WO-2006011047-A1 | ENANTIOSELECTIVE METHOD FOR SEPARING SUBSTITUTED 2-TRIFLUOROMETHYL-2H-CHROMENE-3-CARBOXYLIC ACID DERIVATIVES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-02-02 | — | — | WO | disclosed |
| US-20060020023-A1 | Racemization method | PHARMACIA & UPJOHN COMPANY LLC | 2006-01-26 | — | — | US | disclosed |
| US-20060016683-A1 | Photoracamization method | PHARMACIA & UPJOHN COMPANY LLC | 2006-01-26 | — | — | US | disclosed |
| US-20060020022-A1 | Enantioselective separation method | PHARMACIA & UPJOHN COMPANY LLC | 2006-01-26 | — | — | US | disclosed |
| EP-0398288-B1 | Process for preparing optically active 2-arylalkanoic acids, in particular 2-arylpropionic acids | PUETTER MEDICE CHEM PHARM (DE) | 1995-10-18 | — | — | EP | disclosed |
| EP-0398288-A2 | Process for preparing optically active 2-arylalkanoic acids, in particular 2-arylpropionic acids | MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG (DE) | 1990-11-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194608-A1 | 6-Phenylhex-5-Enoic Acid Derivatives, Process for the Preparation Thereof, Pharmaceutical Compositions Comprising Them, and Therapeutic Uses Thereof | PCSK9, HMGCR, LIPA | TAAR1 4075/4885CYP2D6 43/4885CYP2C19 154/4885 |
| US-20080161308-A1 | e.g. 4-[6-(2-cyclohexylethoxy)-3-oxoindan-5-yloxy]butanoic acid; peroxisome proliferator-activated receptor (PPAR) gamma agonist; antiinflammatory, antidiabetic agent; dyslipidaemia, atherosclerosis, insulin resistance | PPARG, PPARA, PPARD | TAAR1 1170/4885CYP2D6 660/4885CYP2C19 822/4885 |
| US-20080139599-A1 | Phenylbenzoic Acid Derivatives, Processes for the Preparation Thereof, Pharmaceutical Compositions Comprising Them, and Therapeutic Uses Thereof | APOB, PCSK9, TGFB1 | TAAR1 3813/4885CYP2D6 253/4885CYP2C19 63/4885 |
| US-20060020023-A1 | Racemization method | STS, SQLE, HAO2 | TAAR1 778/4885CYP2D6 29/4885CYP2C19 31/4885 |
| US-20060016683-A1 | Photoracamization method | CYP3A43, CRY2, CRY1 | TAAR1 1282/4885CYP2D6 33/4885CYP2C19 20/4885 |
| US-20060020022-A1 | Enantioselective separation method | SLC7A1, SLC10A1, DHCR7 | TAAR1 906/4885CYP2D6 77/4885CYP2C19 240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.