Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 8/20 | 0.37 |
| ▸ | CHRM3 known ✓ | P20309 | 8/20 | 0.37 |
| ▸ | CHRM2 known ✓ | P08172 | 7/20 | 0.36 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17191296 | 0.99 | ADRA2A (0.46) | MAPTBLMADRA2AADRA1ACHRM1 | |
| SCHEMBL17827612 | 0.89 | SMN1; SMN2 (0.34) | L3MBTL1SMN1; SMN2LMNAMEN1HPGD | |
| SCHEMBL17827610 | 0.85 | ALDH1A1 (0.35) | MAPTL3MBTL1SMN1; SMN2LMNATSHR | |
| SCHEMBL17827614 | 0.82 | CRHR1 (0.33) | L3MBTL1SMN1; SMN2LMNATSHRMEN1 | |
| SCHEMBL17192835 | 0.82 | DNM1 (0.40) | BLMCHRM1CHRM3CHRM5CHRM2 | |
| SCHEMBL26784274 | 0.81 | THRB (0.33) | SMN1; SMN2 | |
| SCHEMBL15635791 | 0.81 | ALDH1A1 (0.34) | MAPTL3MBTL1SMN1; SMN2LMNATSHR | |
| SCHEMBL15636584 | 0.79 | TSHR (0.41) | MAPTL3MBTL1SMN1; SMN2LMNATSHR | |
| Hydrochloric Acid SCHEMBL15638141 | 0.79 | — | — | |
| SCHEMBL15637257 | 0.78 | TDP1 (0.32) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180002357-A1 | PROCESS FOR THE PREPARATION OF ACYLPHOSPHANES | ETH ZUERICH (CH) | 2018-01-04 | — | — | US | claimed |
| US-20150299231-A1 | A PROCESS FOR THE PREPARATION OF ACYLPHOSPHANES | ETH ZUERICH (CH) | 2015-10-22 | — | — | US | claimed |
| EP-2903995-A1 | A PROCESS FOR THE PREPARATION OF ACYLPHOSPHANES | ETH Zürich (CH) | 2015-08-12 | — | — | EP | claimed |
| WO-2014053455-A1 | A PROCESS FOR THE PREPARATION OF ACYLPHOSPHANES | ETH Zürich (CH) | 2014-04-10 | — | — | WO | claimed |
| CN-108383874-B | Process for preparing acylphosphanes | 瑞士联邦苏黎世技术大学 | 2021-10-08 | — | — | CN | disclosed |
| EP-3508489-B1 | A PROCESS FOR THE PREPARATION OF ACYLPHOSPHANES | ETH ZUERICH (CH) | 2021-04-14 | — | — | EP | disclosed |
| EP-3508489-A1 | A PROCESS FOR THE PREPARATION OF ACYLPHOSPHANES | ETH Zürich (CH) | 2019-07-10 | — | — | EP | disclosed |
| US-10273258-B2 | Process for the preparation of acylphosphanes | ETH ZUERICH (CH) | 2019-04-30 | — | — | US | disclosed |
| EP-2903995-B1 | A PROCESS FOR THE PREPARATION OF ACYLPHOSPHANES | ETH ZUERICH (CH) | 2019-01-16 | — | — | EP | disclosed |
| US-20180002357-A1 | PROCESS FOR THE PREPARATION OF ACYLPHOSPHANES | ETH ZUERICH (CH) | 2018-01-04 | — | — | US | disclosed |
| US-9701700-B2 | Process for the preparation of acylphosphanes | ETH ZUERICH (CH) | 2017-07-11 | — | — | US | disclosed |
| US-20150299231-A1 | A PROCESS FOR THE PREPARATION OF ACYLPHOSPHANES | ETH ZUERICH (CH) | 2015-10-22 | — | — | US | disclosed |
| EP-2903995-A1 | A PROCESS FOR THE PREPARATION OF ACYLPHOSPHANES | ETH Zürich (CH) | 2015-08-12 | — | — | EP | disclosed |
| WO-2014053455-A1 | A PROCESS FOR THE PREPARATION OF ACYLPHOSPHANES | ETH Zürich (CH) | 2014-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10273258-B2 | Process for the preparation of acylphosphanes | AGPAT5, AGPAT2, PHOSPHO1 | CHRM1 3059/4885CHRM3 4263/4885CHRM2 4142/4885 |
| US-20180002357-A1 | PROCESS FOR THE PREPARATION OF ACYLPHOSPHANES | AGPAT5, AGPAT2, PHOSPHO1 | CHRM1 3059/4885CHRM3 4263/4885CHRM2 4142/4885 |
| US-20150299231-A1 | A PROCESS FOR THE PREPARATION OF ACYLPHOSPHANES | AGPAT5, PHOSPHO1, AGPAT2 | CHRM1 3495/4885CHRM3 4475/4885CHRM2 4379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.