Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 3/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.35 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | HSPA5 | P11021 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17193121 | 0.83 | AKR1C2 (0.33) | AKR1C2AKR1C1AKR1C4AKR1C3TTR | |
| SCHEMBL15495181 | 0.81 | WDR5 (0.41) | AKR1C2AKR1C1AKR1C4AKR1C3TTR | |
| SCHEMBL17193078 | 0.81 | HTT (0.38) | AKR1C2AKR1C1AKR1C4AKR1C3HTT | |
| SCHEMBL19426017 | 0.81 | POLB (0.47) | AKR1C2AKR1C1AKR1C4AKR1C3HTT | |
| SCHEMBL19426130 | 0.80 | TTR (0.34) | AKR1C2AKR1C1AKR1C4AKR1C3TTR | |
| SCHEMBL15680157 | 0.79 | AKR1C2 (0.38) | AKR1C2AKR1C1AKR1C4AKR1C3TTR | |
| SCHEMBL19757625 | 0.76 | TTR (0.52) | AKR1C2AKR1C1AKR1C4AKR1C3TTR | |
| SCHEMBL17191823 | 0.75 | AKR1C2 (0.36) | AKR1C2AKR1C1AKR1C4AKR1C3TTR | |
| SCHEMBL17193009 | 0.75 | SELL (0.38) | TTRHTTSMN1; SMN2CYP2C9HSD17B10 | |
| SCHEMBL15680141 | 0.75 | ALDH1A1 (0.41) | AKR1C2AKR1C1AKR1C4AKR1C3TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170281532-A1 | 2 SUBSTITUTED CEPHEM COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2017-10-05 | — | — | US | disclosed |
| US-20150344502-A1 | CEPHEM COMPOUND | SHIONOGI & CO., LTD. (JP) | 2015-12-03 | — | — | US | disclosed |
| US-20150299223-A1 | 2-SUBSTITUTED CEPHEM COMPOUNDS | GLAXO GROUP LTD (GB) | 2015-10-22 | — | — | US | disclosed |
| WO-2014068388-A1 | 2 SUBSTITUTED CEPHEM COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2014-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170281532-A1 | 2 SUBSTITUTED CEPHEM COMPOUNDS | CEP170, CES2, CMBL | AKR1C2 3287/4885AKR1C1 3747/4885AKR1C4 3625/4885 |
| US-20150344502-A1 | CEPHEM COMPOUND | PRMT6, CEP170, NR0B1 | AKR1C2 3334/4885AKR1C1 3660/4885AKR1C4 3546/4885 |
| US-20150299223-A1 | 2-SUBSTITUTED CEPHEM COMPOUNDS | CEP170, ABL1, CEPT1 | AKR1C2 2706/4885AKR1C1 3386/4885AKR1C4 3084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.