Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.41 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GALR3 | O60755 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19491606 | 0.81 | ALDH1A1 (0.43) | ALOX15ALDH1A1CHRNB2CHRNA4CHRM5 | |
| SCHEMBL20446689 | 0.79 | — | — | |
| SCHEMBL29655367 | 0.79 | — | — | |
| SCHEMBL27529959 | 0.76 | ALOX15 (0.47) | ALOX15ALDH1A1CHRNB2CHRNA4CHRM5 | |
| SCHEMBL4759548 | 0.76 | ALOX15 (0.47) | ALOX15ALDH1A1CHRNB2CHRNA4CHRM5 | |
| SCHEMBL19896370 | 0.76 | ALDH1A1 (0.46) | ALOX15ALDH1A1CHRNB2CHRNA4CHRM5 | |
| SCHEMBL1040130 | 0.76 | ALOX15 (0.43) | ALOX15ALDH1A1CHRNB2CHRNA4CHRM5 | |
| SCHEMBL3205425 | 0.75 | ALDH1A1 (0.50) | ALOX15ALDH1A1CHRNB2CHRNA4CHRM5 | |
| SCHEMBL11826430 | 0.74 | ALOX15 (0.50) | ALOX15ALDH1A1CHRNB2CHRNA4CHRM5 | |
| SCHEMBL260591 | 0.74 | ALOX15 (0.46) | ALOX15ALDH1A1CHRNB2CHRNA4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110178300-A1 | NOVEL SYNTHESIS OF SUBSTITUTED 4-AMINO-PYRIMIDINES | DSM IP ASSETS B.V. (NL) | 2011-07-21 | — | — | US | claimed |
| EP-2307355-A1 | Novel synthesis of substituted 4-amino-pyrimidines | DSM IP Assets B.V. (NL) | 2011-04-13 | — | — | EP | claimed |
| WO-2010010113-A1 | Novel synthesis of substituted 4-amino-pyrimidines | DSM IP ASSETS B.V. (NL) | 2010-01-28 | — | — | WO | claimed |
| US-20080242863-A1 | Process For the Manufacture of a Precursor of Vitamin B1 | DSM IP ASSETS B.V. (NL) | 2008-10-02 | — | — | US | claimed |
| EP-1841745-B1 | PROCESS FOR THE MANUFACTURE OF A PRECURSOR OF VITAMIN B1 | DSM IP ASSETS BV (NL) | 2008-06-04 | — | — | EP | claimed |
| EP-1841745-A2 | PROCESS FOR THE MANUFACTURE OF A PRECURSOR OF VITAMIN B1 | DSMIP Assets B.V. (NL) | 2007-10-10 | — | — | EP | claimed |
| WO-2006079504-A2 | PROCESS FOR THE MANUFACTURE OF A PRECURSOR OF VITAMIN B1 | DSM IP ASSETS B.V. (NL) | 2006-08-03 | — | — | WO | claimed |
| CN-116283843-A | Process for preparing alpha-acetyl-gamma-butyrolactone | 新乡瑞诺药业有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-108299345-B | Preparation method of alpha-acetyl-gamma-butyrolactone | 东北制药集团股份有限公司 | 2021-06-11 | — | — | CN | disclosed |
| EP-2888237-B1 | METHOD FOR PREPARATION OF THIAZOLE DERIVATIVES | DSM IP ASSETS BV (NL) | 2017-10-18 | — | — | EP | disclosed |
| US-9108925-B2 | Process for the manufacture of a precursor of vitamin B1 | DSM IP ASSETS B.V. (NL) | 2015-08-18 | — | — | US | disclosed |
| EP-2307355-B1 | Novel synthesis of substituted 4-amino-pyrimidines | DSM IP ASSETS BV (NL) | 2013-11-06 | — | — | EP | disclosed |
| US-8252927-B2 | Synthesis of substituted 4-amino-pyrimidines | DSM IP ASSETS B.V. (NL) | 2012-08-28 | — | — | US | disclosed |
| US-20110178300-A1 | NOVEL SYNTHESIS OF SUBSTITUTED 4-AMINO-PYRIMIDINES | DSM IP ASSETS B.V. (NL) | 2011-07-21 | — | — | US | disclosed |
| EP-2307355-A1 | Novel synthesis of substituted 4-amino-pyrimidines | DSM IP Assets B.V. (NL) | 2011-04-13 | — | — | EP | disclosed |
| WO-2010010113-A1 | Novel synthesis of substituted 4-amino-pyrimidines | DSM IP ASSETS B.V. (NL) | 2010-01-28 | — | — | WO | disclosed |
| US-20080242863-A1 | Process For the Manufacture of a Precursor of Vitamin B1 | DSM IP ASSETS B.V. (NL) | 2008-10-02 | — | — | US | disclosed |
| EP-1841745-B1 | PROCESS FOR THE MANUFACTURE OF A PRECURSOR OF VITAMIN B1 | DSM IP ASSETS BV (NL) | 2008-06-04 | — | — | EP | disclosed |
| EP-1841745-A2 | PROCESS FOR THE MANUFACTURE OF A PRECURSOR OF VITAMIN B1 | DSMIP Assets B.V. (NL) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006079504-A2 | PROCESS FOR THE MANUFACTURE OF A PRECURSOR OF VITAMIN B1 | DSM IP ASSETS B.V. (NL) | 2006-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242863-A1 | Process For the Manufacture of a Precursor of Vitamin B1 | ADH1B, SLC19A2, ADH4 | ALOX15 278/4885ALDH1A1 107/4885CHRNB2 2699/4885 |
| US-20110178300-A1 | NOVEL SYNTHESIS OF SUBSTITUTED 4-AMINO-PYRIMIDINES | IL4I1, CCNB1, VKORC1 | ALOX15 1214/4885ALDH1A1 831/4885CHRNB2 2092/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.