Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CDC25B | P30305 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23421379 | 0.82 | TSHR (0.52) | MAPTSMN1; SMN2MAPK1RAB9AHCRTR1 | |
| SCHEMBL15729936 | 0.80 | ALDH1A1 (0.48) | MAPTSMN1; SMN2MAPK1RAB9AHCRTR1 | |
| SCHEMBL15730018 | 0.78 | TLR7 (0.47) | MAPTSMN1; SMN2MAPK1RAB9AHCRTR1 | |
| SCHEMBL15730009 | 0.76 | GABRA2 (0.42) | MAPTSMN1; SMN2MAPK1ALOX15KMT2A | |
| SCHEMBL6842436 | 0.75 | CDC25B (0.57) | MAPTSMN1; SMN2MAPK1RAB9AHCRTR1 | |
| SCHEMBL3405737 | 0.75 | MAPK1 (0.59) | MAPTSMN1; SMN2MAPK1RAB9AHCRTR1 | |
| SCHEMBL15729958 | 0.75 | ALDH1A1 (0.42) | MAPTSMN1; SMN2MAPK1RAB9AHCRTR1 | |
| SCHEMBL21822412 | 0.73 | NOD2 (0.54) | MAPTSMN1; SMN2MAPK1RAB9AKMT2A | |
| SCHEMBL3606815 | 0.73 | MAPT (0.46) | MAPTSMN1; SMN2MAPK1RAB9AHCRTR1 | |
| SCHEMBL8277735 | 0.72 | KMT2A (0.44) | MAPTSMN1; SMN2MAPK1RAB9AHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3339302-A1 | PYRIDINE DERIVATIVE | Teijin Pharma Limited (JP) | 2018-06-27 | — | — | EP | disclosed |
| EP-3339302-A1 | PYRIDINE DERIVATIVE | Teijin Pharma Limited (JP) | 2018-06-27 | — | — | EP | disclosed |
| EP-2944633-B1 | PYRIDINE DERIVATIVE | TEIJIN PHARMA LTD (JP) | 2018-01-31 | — | — | EP | disclosed |
| EP-2944633-B1 | PYRIDINE DERIVATIVE | TEIJIN PHARMA LTD (JP) | 2018-01-31 | — | — | EP | disclosed |
| US-20170190694-A1 | PYRIDINE DERIVATIVE | TEIJIN PHARMA LIMITED (JP) | 2017-07-06 | — | — | US | disclosed |
| US-20170190694-A1 | PYRIDINE DERIVATIVE | TEIJIN PHARMA LIMITED (JP) | 2017-07-06 | — | — | US | disclosed |
| US-20170190694-A1 | PYRIDINE DERIVATIVE | TEIJIN PHARMA LIMITED (JP) | 2017-07-06 | — | — | US | disclosed |
| US-9637469-B2 | Pyridine derivative | TEIJIN PHARMA LIMITED (JP) | 2017-05-02 | — | — | US | disclosed |
| US-9637469-B2 | Pyridine derivative | TEIJIN PHARMA LIMITED (JP) | 2017-05-02 | — | — | US | disclosed |
| US-9637469-B2 | Pyridine derivative | TEIJIN PHARMA LIMITED (JP) | 2017-05-02 | — | — | US | disclosed |
| EP-2944633-A1 | PYRIDINE DERIVATIVE | Teijin Pharma Limited (JP) | 2015-11-18 | — | — | EP | disclosed |
| EP-2944633-A1 | PYRIDINE DERIVATIVE | Teijin Pharma Limited (JP) | 2015-11-18 | — | — | EP | disclosed |
| US-20150284358-A1 | PYRIDINE DERIVATIVE | TEIJIN PHARMA LIMITED (JP) | 2015-10-08 | — | — | US | disclosed |
| US-20150284358-A1 | PYRIDINE DERIVATIVE | TEIJIN PHARMA LIMITED (JP) | 2015-10-08 | — | — | US | disclosed |
| US-20150284358-A1 | PYRIDINE DERIVATIVE | TEIJIN PHARMA LIMITED (JP) | 2015-10-08 | — | — | US | disclosed |
| WO-2014077285-A1 | PYRIDINE DERIVATIVE | 帝人ファーマ株式会社 (JP) | 2014-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284358-A1 | PYRIDINE DERIVATIVE | HPRT1, XDH, NUDT1 | MAPT 451/4885SMN1; SMN2 3031/4885MAPK1 444/4885 |
| US-20170190694-A1 | PYRIDINE DERIVATIVE | HPRT1, XDH, NUDT1 | MAPT 451/4885SMN1; SMN2 3031/4885MAPK1 444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.