Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16119617 | 0.87 | HTR7 (0.51) | HTR7CYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL31456048 | 0.81 | MTNR1A (0.48) | CYP1A2CYP2D6CYP2C19KDM4EALDH1A1 | |
| SCHEMBL2497117 | 0.81 | L3MBTL1 (0.51) | CYP1A2CYP2D6CYP2C19KDM4EALDH1A1 | |
| SCHEMBL3720086 | 0.81 | L3MBTL1 (0.47) | CYP1A2CYP2D6CYP2C19KDM4EALDH1A1 | |
| SCHEMBL14448836 | 0.80 | KDM4E (0.51) | HTR7PTPN1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5722672 | 0.79 | L3MBTL1 (0.46) | CYP1A2CYP2D6CYP2C19PTPN1KDM4E | |
| SCHEMBL1962740 | 0.79 | ALDH1A1 (0.56) | HTR7PTPN1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL30129318 | 0.79 | PTPN1 (0.48) | HTR7PTPN1ALDH1A1SMN1; SMN2MTNR1A | |
| SCHEMBL5880249 | 0.78 | NOS3 (0.48) | HTR7PTPN1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL17260308 | 0.77 | MAPT (0.50) | KDM4EALDH1A1SMN1; SMN2MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765039-B2 | Biaryl derivatives as bromodomain inhibitors | ZENITH EPIGENETICS LTD. (CA) | 2017-09-19 | — | — | US | disclosed |
| US-20140140956-A1 | BIARYL DERIVATIVES AS BROMODOMAIN INHIBITORS | RVX THERAPEUTICS INC. (CA) | 2014-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140140956-A1 | BIARYL DERIVATIVES AS BROMODOMAIN INHIBITORS | BRDT, BRD3, BRD4 | HTR7 3027/4885CYP1A2 4421/4885CYP2D6 4503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.