Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.48 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13634449 | 0.82 | L3MBTL1 (0.51) | KDM4EALDH1A1MAPTHPGDATM | |
| SCHEMBL24075695 | 0.80 | APLNR (0.50) | KDM4EALDH1A1MAPTHPGDATM | |
| SCHEMBL30129318 | 0.79 | PTPN1 (0.48) | ALDH1A1MTNR1AMTNR1BPTPN1HTR7 | |
| SCHEMBL8139321 | 0.79 | KDM4E (0.53) | NOS3NOS1KDM4EALDH1A1MAPT | |
| SCHEMBL1962740 | 0.79 | ALDH1A1 (0.56) | NOS3NOS1KDM4EALDH1A1MAPT | |
| SCHEMBL7401331 | 0.79 | NOS3 (0.49) | NOS3NOS1KDM4EALDH1A1MAPT | |
| SCHEMBL15178358 | 0.79 | PTPN1 (0.46) | KDM4EALDH1A1MTNR1AMTNR1BPTPN1 | |
| SCHEMBL20456047 | 0.79 | ALDH1A1 (0.61) | KDM4EALDH1A1L3MBTL1PTPN1HTR7 | |
| SCHEMBL15730490 | 0.78 | HTR7 (0.60) | KDM4EALDH1A1MAPTHPGDL3MBTL1 | |
| SCHEMBL805138 | 0.77 | APLNR (0.66) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045652-B2 | From alkyl boronic esters; intermediates in the preparation of 2-amino-6-(substituted-4-phenoxy)-substituted-pyridines | PFIZER INC (US) | 2006-05-16 | — | — | US | disclosed |
| EP-1519940-A1 | SUBSTITUTED ARYL BORONIC ACIDS, THEIR PREPARATION AND THEIR PRECURSORS | Pfizer Products Inc. (US) | 2005-04-06 | — | — | EP | disclosed |
| US-20040038940-A1 | Processes for preparing substituted aryl boronic acids | PFIZER INC. | 2004-02-26 | — | — | US | disclosed |
| WO-2004005301-A1 | SUBSTITUTED ARYL BORONIC ACIDS, THEIR PREPARATION AND THEIR PRECURSORS | PFIZER PRODUCTS INC. (US) | 2004-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038940-A1 | Processes for preparing substituted aryl boronic acids | NOS1, NOS2, CYP1B1 | NOS3 6/4885NOS1 1/4885KDM4E 665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.