Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.76 |
| ▸ | HPGD | P15428 | 6/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.76 |
| ▸ | MAPT | P10636 | 7/20 | 0.62 |
| ▸ | RAB9A | P51151 | 7/20 | 0.62 |
| ▸ | NPC1 | O15118 | 7/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.60 |
| ▸ | CASP1 | P29466 | 3/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | CASP7 | P55210 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8289404 | 0.83 | ALDH1A1 (0.80) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL15281387 | 0.79 | ALDH1A1 (0.63) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL5794137 | 0.78 | ALDH1A1 (0.78) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL17916667 | 0.77 | HPGD (0.70) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL7004914 | 0.74 | NPC1 (0.61) | ALDH1A1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL14825171 | 0.72 | PKM (0.63) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL7003934 | 0.72 | ALDH1A1 (0.70) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL6997315 | 0.72 | ALDH1A1 (0.60) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL18180597 | 0.71 | L3MBTL1 (0.66) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL7902809 | 0.71 | GRIN2C (1.00) | ALDH1A1KDM4EHPGDKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9261497-B2 | Method of treating cancer with modulators of SCFSkp2 | NEW YORK UNIVERSITY (US) | 2016-02-16 | — | — | US | disclosed |
| US-20140142120-A1 | METHOD OF TREATING CANCER WITH MODULATORS OF SCFSkp2 | NEW YORK UNIVERSITY (US) | 2014-05-22 | — | — | US | disclosed |
| US-20140142120-A1 | METHOD OF TREATING CANCER WITH MODULATORS OF SCFSkp2 | NEW YORK UNIVERSITY (US) | 2014-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142120-A1 | METHOD OF TREATING CANCER WITH MODULATORS OF SCFSkp2 | SKP2, PACSIN2, MDM2 | ALDH1A1 2386/4885KDM4E 785/4885HPGD 3807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.