Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | CSNK2A2 | P19784 | 5/20 | 0.60 |
| ▸ | CSNK2B | P67870 | 5/20 | 0.60 |
| ▸ | CSNK2A1 | P68400 | 5/20 | 0.60 |
| ▸ | CSNK2A3 | Q8NEV1 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674903 | 0.77 | GAA (0.61) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL7001604 | 0.77 | MAPT (0.63) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL5794137 | 0.75 | ALDH1A1 (0.78) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL15731000 | 0.74 | ALDH1A1 (0.76) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL6997315 | 0.73 | ALDH1A1 (0.60) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL4970562 | 0.73 | MAOB (0.82) | NPC1RAB9ASMN1; SMN2CSNK2A2CSNK2B | |
| SCHEMBL8645195 | 0.72 | LMNA (0.67) | NPC1RAB9ASMN1; SMN2CSNK2A2CSNK2B | |
| SCHEMBL29569747 | 0.72 | KDM4E (0.74) | NPC1RAB9ASMN1; SMN2L3MBTL1CSNK2A2 | |
| SCHEMBL1532188 | 0.72 | KDM4E (0.74) | NPC1RAB9ASMN1; SMN2L3MBTL1CSNK2A2 | |
| SCHEMBL13744490 | 0.71 | RAB9A (0.57) | NPC1RAB9ASMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294707-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-03-26 | — | — | EP | claimed |
| US-6414013-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-07-02 | — | — | US | claimed |
| WO-2001098290-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-27 | — | — | WO | claimed |