Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.51 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15733267 | 0.80 | TSHR (0.48) | MEN1KMT2AKCNQ3KCNQ2LMNA | |
| SCHEMBL31740895 | 0.77 | ALDH1A1 (0.58) | MEN1KMT2AMAPTHTTALDH1A1 | |
| SCHEMBL6199779 | 0.75 | MEN1 (0.45) | MEN1KMT2AKCNQ3KCNQ2MAPT | |
| SCHEMBL16562244 | 0.72 | RAB9A (0.74) | MEN1KMT2ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL2128569 | 0.72 | KMT2A (1.00) | MEN1KMT2ASMN1; SMN2LMNACYP1A2 | |
| SCHEMBL9505080 | 0.71 | ALDH2 (0.59) | MEN1KMT2ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL16333801 | 0.71 | KDM4E (0.49) | MEN1KMT2ASMN1; SMN2LMNAMAPT | |
| SCHEMBL11297673 | 0.71 | KDM4E (0.52) | MEN1KMT2ASMN1; SMN2LMNAMAPT | |
| SCHEMBL2839345 | 0.71 | MEN1 (0.68) | MEN1KMT2ASMN1; SMN2LMNAMAPT | |
| SCHEMBL23657593 | 0.70 | LMNA (0.72) | LMNAALDH1A1TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925316-A1 | SUBSTITUTED AMINO-ARYLCARBOXAMIDES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2015-10-07 | — | — | EP | disclosed |
| WO-2014082739-A1 | SUBSTITUTED AMINO-ARYLCARBOXAMIDES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2014-06-05 | — | — | WO | disclosed |
| US-20140148454-A1 | SUBSTITUTED AMINO-ACRYLCARBOXAMIDES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2014-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140148454-A1 | SUBSTITUTED AMINO-ACRYLCARBOXAMIDES AS KCNQ2/3 MODULATORS | KCNJ2, KCNQ1, KCNQ2 | MEN1 4240/4885KMT2A 260/4885KCNQ3 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.