Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.46 |
| ▸ | IDO1 | P14902 | 4/20 | 0.46 |
| ▸ | TDO2 | P48775 | 3/20 | 0.46 |
| ▸ | CNR1 | P21554 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1573848 | 0.89 | IDO1 (0.56) | TSHRHIF1AMAPK1TDP1LMNA | |
| SCHEMBL10639836 | 0.87 | TSHR (0.48) | TSHRHIF1AMAPK1TDP1LMNA | |
| SCHEMBL14033913 | 0.87 | MAPK1 (0.48) | TSHRHIF1AMAPK1TDP1LMNA | |
| SCHEMBL2512140 | 0.87 | CNR1 (0.49) | TSHRHIF1AMAPK1TDP1LMNA | |
| SCHEMBL2909600 | 0.84 | CYP19A1 (0.71) | TSHRHIF1AMAPK1TDP1LMNA | |
| SCHEMBL6075877 | 0.83 | CYP1A2 (0.68) | TSHRHIF1AMAPK1TDP1LMNA | |
| SCHEMBL1978774 | 0.83 | TP53 (0.50) | TSHRHIF1AMAPK1TDP1LMNA | |
| SCHEMBL2518114 | 0.81 | MAOA (0.55) | TSHRHIF1AMAPK1TDP1LMNA | |
| SCHEMBL7562082 | 0.80 | TSHR (0.60) | TSHRHIF1AMAPK1TDP1LMNA | |
| SCHEMBL14033982 | 0.79 | TSHR (0.41) | TSHRHIF1AMAPK1TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 187 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250186450-A1 | COMBINATION THERAPY COMPRISING DGK INHIBITORS and PD-1/PD-L1 INHIBITORS | INCYTE CORPORATION | 2025-06-12 | — | — | US | disclosed |
| WO-2025122695-A1 | COMBINATION THERAPY COMPRISING DGK INHIBITORS AND PD-1/PD-L1 INHIBITORS | INCYTE CORPORATION (US) | 2025-06-12 | — | — | WO | disclosed |
| WO-2025122545-A1 | TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS | INCYTE CORPORATION (US) | 2025-06-12 | — | — | WO | disclosed |
| US-20250179083-A1 | TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS | INCYTE CORPORATION | 2025-06-05 | — | — | US | disclosed |
| EP-4536362-A1 | TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS | Incyte Corporation (US) | 2025-04-16 | — | — | EP | disclosed |
| US-20240400499-A1 | NOVEL AMINO ACID DERIVATIVES | PEPTIDREAM INC (JP) | 2024-12-05 | — | — | US | disclosed |
| US-12018004-B2 | Carbamate compounds and methods of making and using same | H. LUNDBECK A/S (DK) | 2024-06-25 | — | — | US | disclosed |
| WO-2023239768-A1 | TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS | INCYTE CORPORATION (US) | 2023-12-14 | — | — | WO | disclosed |
| US-20230399342-A1 | TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS | INCYTE CORPORATION | 2023-12-14 | — | — | US | disclosed |
| US-20230312499-A1 | CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME | H. LUNDBECK A/S (DK) | 2023-10-05 | — | — | US | disclosed |
| US-4265894-A | TREATING PARKINSON'S DISEASE AND ACROMEGALY | GIST BROCADES, N.V. (NL) | 1981-05-05 | — | — | US | disclosed |
| US-4202896-A | DOPAMINERGIC ACTIVITY | GIST-BROCADES N.V. (NL) | 1980-05-13 | — | — | US | disclosed |
| US-4118561-A | ANTIBACTERIAL, SYNERGISTIC, ANTI-CANCER ACTIVITY, ANTI-FOLIC ACID ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 1978-10-03 | — | — | US | disclosed |
| US-4117168-A | ANTIFUNGAL DI(ARYL)METHYL ALKYL SULFONES | PPG INDUSTRIES, INC. (US) | 1978-09-26 | — | — | US | disclosed |
| US-4103031-A | Control of plant pests with bis(4-chlorophenyl)methyl methyl sulfoxide | PPG INDUSTRIES, INC. (US) | 1978-07-25 | — | — | US | disclosed |
| US-4084005-A | Control of the harmful effects of Fusarium upon plants | PPG INDUSTRIES, INC. (US) | 1978-04-11 | — | — | US | disclosed |
| US-4067909-A | FUNGICIDES | PPG INDUSTRIES, INC. (US) | 1978-01-10 | — | — | US | disclosed |
| US-4064178-A | PESTICIDE, FUNGICIDE, BACTERICIDE | PPG INDUSTRIES, INC. (US) | 1977-12-20 | — | — | US | disclosed |
| US-4017631-A | MICROBIOCIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-04-12 | — | — | US | disclosed |
| US-3991202-A | ANTIMICROBIALS | JANSSEN PHARMACEUTICA N.V. (BE) | 1976-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250186450-A1 | COMBINATION THERAPY COMPRISING DGK INHIBITORS and PD-1/PD-L1 INHIBITORS | DGKG, DCK, DGKA | TSHR 3484/4885HIF1A 2205/4885MAPK1 607/4885 |
| US-20250179083-A1 | TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS | DGKA, DGKI, DGKG | TSHR 2904/4885HIF1A 4735/4885MAPK1 750/4885 |
| US-20230312499-A1 | CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ABHD6, ABHD16A, RABL6 | TSHR 4573/4885HIF1A 3300/4885MAPK1 3735/4885 |
| US-20230399342-A1 | TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS | DGKA, DGKI, DGKG | TSHR 2904/4885HIF1A 4735/4885MAPK1 750/4885 |
| US-12018004-B2 | Carbamate compounds and methods of making and using same | ABHD6, ABHD16A, RABL6 | TSHR 4573/4885HIF1A 3300/4885MAPK1 3735/4885 |
| US-20240400499-A1 | NOVEL AMINO ACID DERIVATIVES | BCAT1, BCAT2, PELP1 | TSHR 2791/4885HIF1A 3000/4885MAPK1 3478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.