Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 10/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | PGR | P06401 | 2/20 | 0.61 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | SHBG | P04278 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | AR | P10275 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL332585 | 0.85 | HIF1A (0.69) | HIF1ALMNANR3C1SMN1; SMN2NR3C2 | |
| SCHEMBL29064801 | 0.84 | HIF1A (0.73) | HIF1ALMNANR3C1SMN1; SMN2NR3C2 | |
| SCHEMBL11814284 | 0.84 | HIF1A (0.81) | HIF1ALMNANR3C1SMN1; SMN2NR3C2 | |
| SCHEMBL16020569 | 0.82 | HIF1A (0.78) | HIF1ALMNANR3C1SMN1; SMN2NR3C2 | |
| SCHEMBL27475747 | 0.82 | HIF1A (0.69) | HIF1ALMNANR3C1SMN1; SMN2NR3C2 | |
| SCHEMBL3108473 | 0.82 | HIF1A (0.69) | HIF1ALMNANR3C1SMN1; SMN2NR3C2 | |
| SCHEMBL8071547 | 0.81 | HIF1A (0.77) | HIF1ALMNANR3C1SMN1; SMN2NR3C2 | |
| SCHEMBL7614974 | 0.81 | HIF1A (0.77) | HIF1ALMNANR3C1SMN1; SMN2NR3C2 | |
| SCHEMBL9437393 | 0.81 | HIF1A (0.75) | HIF1ALMNANR3C1SMN1; SMN2NR3C2 | |
| SCHEMBL7519660 | 0.80 | HIF1A (0.75) | HIF1ALMNANR3C1SMN1; SMN2NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210128584-A1 | USE OF GLUCOCORTICOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS | CORCEPT THERAPEUTICS INCORPORATED | 2021-05-06 | — | — | US | disclosed |
| US-20140005158-A1 | USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS | CORCEPT THERAPEUTICS, INC. (US) | 2014-01-02 | — | — | US | disclosed |
| US-20110166115-A1 | USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS | CORCEPT THERAPEUTICS, INC. (US) | 2011-07-07 | — | — | US | disclosed |
| EP-2306830-A1 | USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS | Corcept Therapeutics, Inc. (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2010002901-A1 | USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS | CORCEPT THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166115-A1 | USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS | CRHR1, NR3C1, CRH | HIF1A 2068/4885LMNA 1279/4885NR3C1 2/4885 |
| US-20140005158-A1 | USE OF MIFEPRISTONE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS | CRHR1, NR3C1, CRH | HIF1A 2068/4885LMNA 1279/4885NR3C1 2/4885 |
| US-20210128584-A1 | USE OF GLUCOCORTICOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS | NR3C1, CRHR1, NR3C2 | HIF1A 3070/4885LMNA 2382/4885NR3C1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.