SCHEMBL1573904

SCHEMBL1573904

Cn1c(C(F)(F)F)cc(=O)n(-c2ccc(Cl)c(-c3nnnn3CC3CC3)c2)c1=O

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.37
KMT2A Q03164 1/20 0.37
MAPT P10636 2/20 0.34
CRHR1 P34998 9/20 0.33
L3MBTL1 Q9Y468 2/20 0.32
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
NOTUM Q6P988 1/20 0.32
CRHR2 Q13324 1/20 0.32
SLC6A2 P23975 1/20 0.32
SLC6A4 P31645 1/20 0.32
SLC6A3 Q01959 1/20 0.32
GRM2 Q14416 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2839349 0.88 BRD9 (0.38) KMT2AALDH1A1NOTUM
SCHEMBL2839228 0.85 NOTUM (0.33) KMT2ANOTUM
SCHEMBL2836047 0.85 ALDH1A1 (0.39) ALDH1A1NOTUM
SCHEMBL2836068 0.85 P2RX7 (0.43) POLBKMT2AL3MBTL1ALDH1A1
SCHEMBL2836856 0.85 NOTUM (0.33) ALDH1A1NOTUM
SCHEMBL2833127 0.85 RAB9A (0.39) ALDH1A1NOTUM
SCHEMBL2835974 0.85 P2RX7 (0.43) POLBL3MBTL1ALDH1A1LMNANOTUM
SCHEMBL2834932 0.84 NOTUM (0.32) NOTUM
SCHEMBL2833836 0.84 NOTUM (0.37) MAPTL3MBTL1ALDH1A1LMNANOTUM
SCHEMBL2836987 0.82 CNR1 (0.35) POLBKMT2AMAPTCRHR1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7754880-B2 Uracils having a herbicidal activity ISAGRO RICERCA S.R.L. (IT) 2010-07-13 US claimed
US-20060025591-A1 New uracils having a herbicidal activity ISEM S.R.L. (IT) 2006-02-02 US claimed
EP-1585737-B8 URACILS HAVING A HERBICIDAL ACTIVITY ISAGRO SPA (IT) 2011-04-13 EP disclosed
US-7754880-B2 Uracils having a herbicidal activity ISAGRO RICERCA S.R.L. (IT) 2010-07-13 US disclosed
US-20060025591-A1 New uracils having a herbicidal activity ISEM S.R.L. (IT) 2006-02-02 US disclosed
EP-1585737-A2 URACILS HAVING A HERBICIDAL ACTIVITY Isagro Ricerca S.r.l. (IT) 2005-10-19 EP disclosed
WO-2004056785-A2 URACILS HAVING A HERBICIDAL ACTIVITY ISAGRO RICERCA S.R.L. (IT) 2004-07-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060025591-A1 New uracils having a herbicidal activity UNG, DDT, UMPS POLB 69/4885KMT2A 1729/4885MAPT 3499/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.