SCHEMBL15745809

SCHEMBL15745809

Cc1cc(C(=O)Cl)ccc1-c1ccc(C(=O)Cl)cc1C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 2/20 0.39
RARB P10826 1/20 0.39
GLA P06280 1/20 0.38
POLB P06746 1/20 0.38
GAA P10253 1/20 0.38
TSHR P16473 1/20 0.38
GPBAR1 Q8TDU6 6/20 0.38
AKR1C3 P42330 3/20 0.37
AKR1C2 P52895 3/20 0.37
NPSR1 Q6W5P4 2/20 0.37
MEN1 O00255 1/20 0.37
NPC1 O15118 1/20 0.37
MAPT P10636 1/20 0.37
HTT P42858 1/20 0.37
RAB9A P51151 1/20 0.37
KMT2A Q03164 1/20 0.37
RORC P51449 1/20 0.36
ALDH1A1 P00352 1/20 0.36
PLA2G1B P04054 1/20 0.36
CYP1A2 P05177 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30892335 0.90 GLA (0.45) GLAPOLBGAATSHRAKR1C3
SCHEMBL278277 0.90 GLA (0.45) GLAPOLBGAATSHRAKR1C3
SCHEMBL5784173 0.89 AKR1C3 (0.45) TRPV1GPBAR1AKR1C3AKR1C2NPSR1
SCHEMBL22199854 0.85 KIF11 (0.46) GLAPOLBGAATSHRAKR1C3
SCHEMBL2154161 0.84 HSD17B1 (0.43) RARBGAATSHRNPC1MAPT
SCHEMBL15385132 0.83 NOTUM (0.42) GPBAR1NPSR1MEN1NPC1MAPT
SCHEMBL2891169 0.83 ADCY8 (0.43) GPBAR1NPSR1MEN1NPC1MAPT
SCHEMBL15745795 0.83 TRPV1 (0.39) TRPV1RARBGLAPOLBGAA
SCHEMBL28424524 0.80 ADH5 (0.48) AKR1C3AKR1C2SRD5A2KIF11ADH5
SCHEMBL15247155 0.78 GLA (0.36) GLAPOLBGAATSHRAKR1C3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140148548-A1 Fluorine-Containing Polymerizable Monomer And Polymer Compound Using Same CENTRAL GLASS COMPANY, LIMITED (JP) 2014-05-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140148548-A1 Fluorine-Containing Polymerizable Monomer And Polymer Compound Using Same AFF4, AFF2, AFF1 TRPV1 2968/4885RARB 2970/4885GLA 4704/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.