SCHEMBL278277

SCHEMBL278277

O=C(Cl)c1ccc(-c2ccc(C(=O)Cl)cc2C(F)(F)F)c(C(F)(F)F)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLA P06280 1/20 0.45
POLB P06746 1/20 0.45
GAA P10253 1/20 0.45
TSHR P16473 1/20 0.45
ADH5 P11766 1/20 0.40
RAB9A P51151 2/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C19 P33261 1/20 0.39
AKR1C3 P42330 6/20 0.38
AKR1C2 P52895 6/20 0.38
KCNQ3 O43525 1/20 0.38
KCNQ2 O43526 1/20 0.38
KCNE1 P15382 1/20 0.38
KCNQ1 P51787 1/20 0.38
CES2 O00748 3/20 0.38
CES1 P23141 1/20 0.38
KIF11 P52732 1/20 0.38
NOTUM Q6P988 1/20 0.38
SRD5A2 P31213 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30892335 1.00 GLA (0.45) GLAPOLBGAATSHRADH5
SCHEMBL22199854 0.91 KIF11 (0.46) GLAPOLBGAATSHRRAB9A
SCHEMBL15745809 0.90 TRPV1 (0.39) GLAPOLBGAATSHRADH5
SCHEMBL28424524 0.89 ADH5 (0.48) ADH5AKR1C3AKR1C2KIF11SRD5A2
SCHEMBL15247155 0.87 GLA (0.36) GLAPOLBGAATSHRADH5
SCHEMBL31542017 0.86 NOTUM (0.42) RAB9ACYP1A2CYP2D6CYP2C19KCNQ3
SCHEMBL2680326 0.86 NOTUM (0.42) RAB9ACYP1A2CYP2D6CYP2C19KCNQ3
SCHEMBL10074663 0.83 RXRA (0.40) SRD5A2
SCHEMBL1794695 0.82 KDR (0.54) GAANOTUMMAPTNPSR1KDR
SCHEMBL12097542 0.82 MAPT (0.54) GAARAB9ACYP1A2CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020141713-A1 METHOD FOR PREPARING POLYAMIC ACID COMPOSITION CONTAINING NOVEL DICARBONYL COMPOUND, POLYAMIC ACID COMPOSITION, METHOD FOR MANUFACTURING POLYAMIDE-IMIDE FILM USING SAME, AND POLYAMIDE-IMIDE FILM PRODUCED BY SAME MANUFACTURING METHOD 주식회사 대림코퍼레이션 2020-07-09 WO disclosed
WO-2020138041-A1 OPTICAL FILM, FLEXIBLE DISPLAY DEVICE, AND POLYAMIDE-IMIDE RESIN 住友化学株式会社 2020-07-02 WO disclosed
WO-2020138042-A1 OPTICAL FILM, FLEXIBLE DISPLAY DEVICE AND POLYAMIDE-IMIDE RESIN 住友化学株式会社 2020-07-02 WO disclosed
WO-2020138044-A1 POLYAMIDE-BASED RESIN, OPTICAL FILM, AND FLEXIBLE DISPLAY DEVICE 住友化学株式会社 2020-07-02 WO disclosed
WO-2014084188-A1 FLUORINE-CONTAINING POLYMERIZABLE MONOMER AND POLYMER COMPOUND USING SAME セントラル硝子株式会社 (JP) 2014-06-05 WO disclosed
US-20140148548-A1 Fluorine-Containing Polymerizable Monomer And Polymer Compound Using Same CENTRAL GLASS COMPANY, LIMITED (JP) 2014-05-29 US disclosed
US-8133550-B2 Good breaking elongation characteristics, achievable high sensitivity and high film remaining rate, little in pattern size fluctuation at the heating time after lithographic process, capable of stable pattern formation; manufacturing a semiconductor device FUJIFILM CORPORATION (JP) 2012-03-13 US disclosed
US-20080076849-A1 POLYBENZOXAZOLE PRECURSOR, PHOTOSENSITIVE RESIN COMPOSITION USING THE SAME, AND MANUFACTURING METHOD OF SEMICONDUCTOR DEVICE FUJIFILM CORPORATION (JP) 2008-03-27 US disclosed
EP-0788526-B1 NEGATIVE BIREFRINGENT RIGID ROD POLYMER FILMS UNIV AKRON (US) 2003-08-20 EP disclosed
US-6410677-B1 Resin composition for insulating material, and insulating material produced from said resin composition SUMITOMO BAKELITE COMPANY LIMITED (JP) 2002-06-25 US disclosed
US-5580950-A POLYESTERS, POLYAMIDES, POLYAMIDEIMIDE, OR POLYESTERIMIDE THE UNIVERSITY OF AKRON (US) 1996-12-03 US disclosed
EP-0380338-B1 Compensator for liquid crystal display NIPPON OIL CO LTD (JP) 1995-04-05 EP disclosed
US-5326496-A Black and white screen, polyesters, polyamides, polycarbonates NIPPON OIL COMPANY LIMITED (JP) 1994-07-05 US disclosed
EP-0380338-A2 Compensator for liquid crystal display NIPPON OIL CO., LTD. (JP) 1990-08-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140148548-A1 Fluorine-Containing Polymerizable Monomer And Polymer Compound Using Same AFF4, AFF2, AFF1 GLA 4704/4885POLB 2934/4885GAA 4820/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.