Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | EIF4E | P06730 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MASP2 | O00187 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | S100A4 | P26447 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775915 | 0.86 | MAPT (0.40) | KMT2AMEN1EIF4EMAPTRECQL | |
| SCHEMBL15775583 | 0.85 | TDP1 (0.49) | KMT2AMEN1LMNAMAPTRECQL | |
| SCHEMBL15775768 | 0.84 | KMT2A (0.40) | KMT2AMEN1LMNAEIF4EMAPT | |
| SCHEMBL15775423 | 0.81 | PDCD1 (0.38) | MAPTPARP1PDCD1CD274 | |
| SCHEMBL15775318 | 0.81 | HTR7 (0.42) | KMT2AMEN1EIF4EMAPTRECQL | |
| SCHEMBL15775785 | 0.80 | TNKS (0.41) | MAPTPARP1PDCD1CD274 | |
| SCHEMBL4763729 | 0.74 | PDCD1 (0.43) | MAPTPOLBPARP1PDCD1CD274 | |
| SCHEMBL2965327 | 0.72 | ALDH1A1 (0.65) | KMT2AMEN1LMNAEIF4EMAPT | |
| SCHEMBL15775233 | 0.69 | MAPT (0.43) | KMT2AMAPTRECQLMCL1RXFP1 | |
| SCHEMBL15775159 | 0.69 | PARP1 (0.36) | MAPTPARP1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |