Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | F10 | P00742 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 7/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6935548 | 0.87 | ALDH1A1 (0.65) | ALDH1A1KDM4EF10RAB9ANPC1 | |
| SCHEMBL7574902 | 0.86 | TP53 (0.55) | ALDH1A1KDM4EF10RAB9ANPC1 | |
| SCHEMBL15775319 | 0.86 | KDM4E (0.59) | ALDH1A1KDM4EF10RAB9ANPC1 | |
| SCHEMBL15775601 | 0.84 | KDM4E (0.61) | ALDH1A1KDM4EKMT2APOLBKCNK9 | |
| SCHEMBL15775437 | 0.83 | KDM4E (0.57) | KDM4ERAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL15775229 | 0.83 | KDM4E (0.57) | ALDH1A1KDM4EF10RAB9ANPC1 | |
| SCHEMBL15775402 | 0.83 | KDM4E (0.77) | KDM4ERAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL7249253 | 0.82 | F10 (0.69) | ALDH1A1F10RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL21870513 | 0.82 | ALDH1A1 (0.59) | ALDH1A1KDM4EF10RAB9ANPC1 | |
| SCHEMBL15775220 | 0.81 | KDM4E (0.58) | KDM4ERAB9ANPC1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |