Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL15775523 | 0.88 | LAP3 (0.40) | MAOBIDO1 | |
| SCHEMBL15775980 | 0.86 | LAP3 (0.41) | MAOBIDO1 | |
| Bromide SCHEMBL15775614 | 0.81 | GRM2 (0.40) | MAOBIDO1 | |
| SCHEMBL15775665 | 0.80 | ALDH1A1 (0.40) | — | |
| Bromide SCHEMBL15775416 | 0.78 | ADORA1 (0.43) | MAOBIDO1 | |
| Bromide SCHEMBL15775859 | 0.78 | XDH (0.41) | XDHMAOB | |
| Bromide SCHEMBL15775833 | 0.76 | RXFP1 (0.34) | MAOBCLK4 | |
| Bromide SCHEMBL15775323 | 0.76 | TYR (0.41) | MAOB | |
| SCHEMBL15775366 | 0.74 | RAB9A (0.38) | — | |
| Bromide SCHEMBL15776793 | 0.74 | BCHE (0.35) | MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |