Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.32 |
| ▸ | ELANE | P08246 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4859621 | 0.84 | ELANE (0.42) | GCGRMEN1MAPTKMT2AHTT | |
| SCHEMBL15775198 | 0.80 | MAPT (0.39) | SMN1; SMN2KCNH2MAPTKMT2AHTT | |
| SCHEMBL516238 | 0.77 | PTPN1 (0.40) | SMN1; SMN2KCNH2PTPN1GAAGPR84 | |
| SCHEMBL423378 | 0.73 | PARP1 (0.40) | PARP1DHFRPABPC1ALDH1A1TSHR | |
| SCHEMBL472760 | 0.68 | PTPN1 (0.42) | KCNH2PTPN1GPR84TSHRNR1H2 | |
| SCHEMBL21065455 | 0.68 | PTPN1 (0.42) | KCNH2PTPN1GPR84TSHRNR1H2 | |
| SCHEMBL15775665 | 0.67 | ALDH1A1 (0.40) | PARP1SMN1; SMN2MAPTGAAKDM4E | |
| SCHEMBL7913644 | 0.66 | TDP1 (0.39) | PTPN1NR1H2NR1H3 | |
| SCHEMBL15775307 | 0.65 | UGCG (0.41) | SMN1; SMN2MEN1MAPTKMT2AKDM4E | |
| SCHEMBL15775407 | 0.64 | CCNE2 (0.44) | PARP1SMN1; SMN2PTPN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |