SCHEMBL423378

SCHEMBL423378

CC1=NC(=O)c2cccc(N)c2C1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 3/20 0.40
TYR P14679 1/20 0.36
DPP4 P27487 1/20 0.35
CYP3A4 P08684 1/20 0.34
TSHR P16473 1/20 0.34
PIK3CA P42336 1/20 0.34
ADORA2A P29274 2/20 0.34
PTPRC P08575 1/20 0.34
BRD4 O60885 2/20 0.33
TYMS P04818 1/20 0.32
ELANE P08246 1/20 0.32
CD44 P16070 1/20 0.31
ALDH1A1 P00352 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
DHFR P00374 1/20 0.31
ACHE P22303 2/20 0.31
TNF P01375 1/20 0.31
IL1B P01584 1/20 0.31
IKZF1 Q13422 1/20 0.31
DDB1 Q16531 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15775349 0.79 PARP1 (0.37) PARP1TYRADORA2APTPRCALDH1A1
SCHEMBL15775366 0.79 RAB9A (0.38) PARP1TYRTSHRADORA2AALDH1A1
SCHEMBL15775665 0.76 ALDH1A1 (0.40) PARP1TYRADORA2APTPRCALDH1A1
SCHEMBL15775307 0.73 UGCG (0.41) ADORA2AALDH1A1ACHE
SCHEMBL15775596 0.73 PARP1 (0.39) PARP1TSHRELANEALDH1A1DHFR
Bromide SCHEMBL15775497 0.72 UGCG (0.40) ADORA2AALDH1A1ACHE
SCHEMBL15775407 0.72 CCNE2 (0.44) PARP1TSHRALDH1A1L3MBTL1
Bromide SCHEMBL15775675 0.72 ADORA2A (0.36) PARP1TYRTSHRADORA2APTPRC
Bromide SCHEMBL15776793 0.72 BCHE (0.35) PARP1TYRTSHRADORA2APTPRC
SCHEMBL1261840 0.71 PARP1 (0.42) PARP1TYRDPP4ADORA2APTPRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120022026-A1 METHOD OF TREATING CANCER ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM (NL) 2012-01-26 US claimed
EP-2387403-A1 METHOD OF TREATING CANCER Academisch Medisch Centrum bij de Universiteit van Amsterdam (NL) 2011-11-23 EP claimed
US-20110253692-A1 Electrical heater for vehicle windshields and windows SCHAUBLE RICHARD EGON 2011-10-20 US claimed
WO-2010082821-A1 METHOD OF TREATING CANCER ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) 2010-07-22 WO claimed
WO-2010082813-A1 METHOD OF TREATING CANCER ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) 2010-07-22 WO claimed
US-20120022026-A1 METHOD OF TREATING CANCER ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM (NL) 2012-01-26 US disclosed
EP-2387403-A1 METHOD OF TREATING CANCER Academisch Medisch Centrum bij de Universiteit van Amsterdam (NL) 2011-11-23 EP disclosed
US-20110253692-A1 Electrical heater for vehicle windshields and windows SCHAUBLE RICHARD EGON 2011-10-20 US disclosed
WO-2010082821-A1 METHOD OF TREATING CANCER ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) 2010-07-22 WO disclosed
WO-2010082813-A1 METHOD OF TREATING CANCER ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) 2010-07-22 WO disclosed