Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 4/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.37 |
| ▸ | HTR3B | O95264 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | HTR3A | P46098 | 3/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | BPTF | Q12830 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1579973 | 1.00 | ADRB1 (0.41) | ADRB1CSNK1DMAPK11MAPK14CYP1A2 | |
| SCHEMBL1579251 | 0.89 | BPTF (0.43) | ADRB1CSNK1DMAPK11MAPK14CYP1A2 | |
| SCHEMBL1579254 | 0.89 | BPTF (0.43) | ADRB1CSNK1DMAPK11MAPK14CYP1A2 | |
| SCHEMBL1579440 | 0.89 | BPTF (0.43) | ADRB1CSNK1DMAPK11MAPK14CYP1A2 | |
| SCHEMBL1579989 | 0.85 | HRH4 (0.43) | CSNK1DMAPK14CYP1A2CYP2C19SIGMAR1 | |
| SCHEMBL27836317 | 0.79 | ADRB1 (0.43) | ADRB1CSNK1DMAPK11MAPK14CYP1A2 | |
| SCHEMBL1579220 | 0.78 | HSD11B1 (0.43) | ALDH1A1MAPTKDM4EMAPK1 | |
| SCHEMBL1579604 | 0.77 | ALDH1A1 (0.44) | CYP1A2CYP2C19ALDH1A1KDM4EHTT | |
| SCHEMBL1579606 | 0.77 | ALDH1A1 (0.44) | CYP1A2CYP2C19ALDH1A1KDM4EHTT | |
| SCHEMBL2954143 | 0.77 | MAPK14 (0.60) | ADRB1CSNK1DMAPK11MAPK14CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8530474-B2 | Substituted 6-(1-piperazinyl)-pyridazines as 5-HT6 receptor antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2013-09-10 | — | — | US | disclosed |
| EP-2310374-B1 | SUBSTITUTED 6- (1-PIPERAZINYL) -PYRIDAZINES AS 5-HT6 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2012-10-31 | — | — | EP | disclosed |
| US-20110112107-A1 | SUBSTITUTED 6-(1-PIPERAZINYL)-PYRIDAZINES AS 5-HT6 RECEPTOR ANTAGONISTS | JANSSEN-CILAG S.A. (ES) | 2011-05-12 | — | — | US | disclosed |
| EP-2310374-A1 | SUBSTITUTED 6- (1-PIPERAZINYL) -PYRIDAZINES AS 5-HT6 RECEPTOR ANTAGONISTS | Janssen Pharmaceutica N.V. (BE) | 2011-04-20 | — | — | EP | disclosed |
| WO-2010000456-A1 | SUBSTITUTED 6- (1-PIPERAZINYL) -PYRIDAZINES AS 5-HT6 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112107-A1 | SUBSTITUTED 6-(1-PIPERAZINYL)-PYRIDAZINES AS 5-HT6 RECEPTOR ANTAGONISTS | HTR6, HTR5A, HTR1A | ADRB1 112/4885CSNK1D 1971/4885MAPK11 3338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.