Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.57 |
| ▸ | BLM | P54132 | 7/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.57 |
| ▸ | TP53 | P04637 | 5/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | CDC25B | P30305 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MAOA | P21397 | 2/20 | 0.57 |
| ▸ | MAOB | P27338 | 2/20 | 0.57 |
| ▸ | ATM | Q13315 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | CDC25A | P30304 | 2/20 | 0.57 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.57 |
| ▸ | TST | Q16762 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16879448 | 0.77 | MAOA (0.52) | MAPTBLMSMN1; SMN2CYP3A4TP53 | |
| Caulibugulone A SCHEMBL2555738 | 0.77 | MAPT (0.63) | MAPTBLMSMN1; SMN2CYP3A4TP53 | |
| SCHEMBL11088784 | 0.77 | CDC25B (0.61) | MAPTBLMSMN1; SMN2CYP3A4TP53 | |
| SCHEMBL30616365 | 0.74 | MAOA (0.86) | MAPTBLMSMN1; SMN2CYP3A4TP53 | |
| SCHEMBL20618218 | 0.74 | MAOA (0.77) | MAPTBLMSMN1; SMN2CYP3A4TP53 | |
| SCHEMBL31112247 | 0.74 | MAOA (0.77) | MAPTBLMSMN1; SMN2CYP3A4TP53 | |
| SCHEMBL8417659 | 0.74 | MAOA (0.86) | MAPTBLMSMN1; SMN2CYP3A4TP53 | |
| SCHEMBL16685145 | 0.74 | MAOA (0.70) | MAPTBLMSMN1; SMN2CYP3A4TP53 | |
| Menadione SCHEMBL1364028 | 0.73 | MAPT (1.00) | MAPTBLMSMN1; SMN2CYP3A4TP53 | |
| Menadione SCHEMBL25970 | 0.73 | MAPT (1.00) | MAPTBLMSMN1; SMN2CYP3A4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2691372-B1 | TOTAL SYNTHESIS OF REDOX-ACTIVE 1.4-NAPHTHOQUINONES AND THEIR METABOLITES AND THEIR THERAPEUTIC USE AS ANTIMALARIAL AND SCHISTOMICIDAL AGENTS | CENTRE NAT RECH SCIENT (FR) | 2019-10-16 | — | — | EP | disclosed |
| US-20150344404-A1 | PDK4 INHIBITOR AND USE THEREOF | THE KITASATO INSTITUTE (JP) | 2015-12-03 | — | — | US | disclosed |
| US-20150344404-A1 | PDK4 INHIBITOR AND USE THEREOF | THE KITASATO INSTITUTE (JP) | 2015-12-03 | — | — | US | disclosed |
| EP-2939668-A1 | PDK4 INHIBITOR AND USE THEREOF | The Kitasato Institute (JP) | 2015-11-04 | — | — | EP | disclosed |
| WO-2014103321-A1 | PDK4 INHIBITOR AND USE THEREOF | 学校法人北里研究所 (JP) | 2014-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344404-A1 | PDK4 INHIBITOR AND USE THEREOF | PDK4, PDK3, PDK2 | MAPT 2524/4885BLM 3394/4885SMN1; SMN2 4431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.