Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15869846 | 0.87 | FAAH (0.48) | FAAHMMP2MMP13MMP14TP53 | |
| SCHEMBL14799971 | 0.86 | MMP13 (0.48) | FAAHMMP2MMP13MMP14TP53 | |
| SCHEMBL15869834 | 0.85 | POLB (0.50) | KDM4EPOLBALDH1A1KMT2AMEN1 | |
| SCHEMBL15868151 | 0.84 | SMN1; SMN2 (0.45) | FAAHMMP2MMP13MMP14KDM4E | |
| SCHEMBL4694993 | 0.84 | FAAH (0.63) | FAAHMMP2MMP13MMP14TP53 | |
| SCHEMBL14799919 | 0.81 | MMP2 (0.46) | FAAHMMP2MMP13MMP14KDM4E | |
| SCHEMBL17319167 | 0.79 | MMP2 (0.44) | FAAHMMP2MMP13MMP14ALDH1A1 | |
| SCHEMBL15869830 | 0.77 | CHRNA7 (0.47) | FAAHMMP2MMP13MMP14TP53 | |
| SCHEMBL15869867 | 0.77 | FAAH (0.45) | FAAHMMP2MMP13MMP14KDM4E | |
| SCHEMBL3435464 | 0.77 | MAPT (0.50) | FAAHKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9078899-B2 | Pyrazolyl-based carboxamides II | GRUENENTHAL GMBH (DE) | 2015-07-14 | — | — | US | disclosed |
| US-9078899-B2 | Pyrazolyl-based carboxamides II | GRUENENTHAL GMBH (DE) | 2015-07-14 | — | — | US | disclosed |
| WO-2014108336-A1 | PYRAZOLYL-BASED CARBOXAMIDES II AS CRAC CHANNEL INHIBITORS | Grünenthal GmbH (DE) | 2014-07-17 | — | — | WO | disclosed |
| US-20140194452-A1 | Pyrazolyl-Based Carboxamides II | Grünenthal GmbH (DE) | 2014-07-10 | — | — | US | disclosed |
| US-20140194452-A1 | Pyrazolyl-Based Carboxamides II | Grünenthal GmbH (DE) | 2014-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140194452-A1 | Pyrazolyl-Based Carboxamides II | AADAC, VDAC2, NLRP3 | FAAH 1408/4885MMP2 4292/4885MMP13 2958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.