Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.45 |
| ▸ | MMP13 | P45452 | 3/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17381180 | 0.87 | MMP2 (0.43) | MMP13MMP2MMP14ALDH1A1GAA | |
| SCHEMBL15868129 | 0.83 | FAAH (0.47) | FAAHMMP13MMP2MMP14ALDH1A1 | |
| SCHEMBL21605639 | 0.83 | FAAH (0.41) | FAAHMMP13MMP2MMP14KMT2A | |
| SCHEMBL15862193 | 0.83 | ALDH1A1 (0.45) | KMT2AALDH1A1MEN1GAAKDM4E | |
| SCHEMBL20656276 | 0.82 | FAAH (0.56) | FAAHMMP13MMP2MMP14ALDH1A1 | |
| SCHEMBL15868156 | 0.80 | FAAH (0.46) | FAAHMMP13MMP2MMP14KDM4E | |
| SCHEMBL15868122 | 0.80 | SMN1; SMN2 (0.45) | FAAHMMP13MMP2MMP14ALDH1A1 | |
| SCHEMBL15869830 | 0.80 | CHRNA7 (0.47) | FAAHMMP13MMP2MMP14KDM4E | |
| SCHEMBL17375118 | 0.80 | FAAH (0.52) | FAAHMMP13MMP2MMP14KMT2A | |
| SCHEMBL14799971 | 0.80 | MMP13 (0.48) | FAAHMMP13MMP2MMP14MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015197188-A1 | PYRAZOLYL-BASED CARBOXAMIDES AS CRAC INHIBITORS | Grünenthal GmbH (DE) | 2015-12-30 | — | — | WO | disclosed |
| WO-2015197188-A1 | PYRAZOLYL-BASED CARBOXAMIDES AS CRAC INHIBITORS | Grünenthal GmbH (DE) | 2015-12-30 | — | — | WO | disclosed |
| US-9078899-B2 | Pyrazolyl-based carboxamides II | GRUENENTHAL GMBH (DE) | 2015-07-14 | — | — | US | disclosed |
| US-9078899-B2 | Pyrazolyl-based carboxamides II | GRUENENTHAL GMBH (DE) | 2015-07-14 | — | — | US | disclosed |
| WO-2014108336-A1 | PYRAZOLYL-BASED CARBOXAMIDES II AS CRAC CHANNEL INHIBITORS | Grünenthal GmbH (DE) | 2014-07-17 | — | — | WO | disclosed |
| US-20140194452-A1 | Pyrazolyl-Based Carboxamides II | Grünenthal GmbH (DE) | 2014-07-10 | — | — | US | disclosed |
| US-20140194452-A1 | Pyrazolyl-Based Carboxamides II | Grünenthal GmbH (DE) | 2014-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140194452-A1 | Pyrazolyl-Based Carboxamides II | AADAC, VDAC2, NLRP3 | FAAH 1408/4885MMP13 2958/4885MMP2 4292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.