Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 10/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15908544 | 0.86 | SMN1; SMN2 (0.45) | AGTR1AGTR2TBXA2RJAK2JAK1 | |
| SCHEMBL9979855 | 0.86 | BACE1 (0.49) | TBXA2RJAK2JAK1TYK2JAK3 | |
| Hydrochloric Acid SCHEMBL15301119 | 0.85 | BACE1 (0.48) | TBXA2RJAK2JAK1TYK2JAK3 | |
| SCHEMBL7949000 | 0.84 | PIK3CD (0.44) | AGTR1AGTR2TBXA2R | |
| SCHEMBL5109530 | 0.83 | AGTR1 (0.48) | AGTR1AGTR2TBXA2RMEN1KMT2A | |
| Bromide SCHEMBL5929370 | 0.82 | AGTR1 (0.47) | AGTR1AGTR2TBXA2RMEN1KMT2A | |
| SCHEMBL7741401 | 0.81 | MEN1 (0.59) | MEN1KMT2A | |
| SCHEMBL7745377 | 0.80 | TSHR (0.50) | AGTR1AGTR2TBXA2R | |
| SCHEMBL15908530 | 0.78 | AGTR1 (0.39) | AGTR1AGTR2TBXA2RJAK2JAK1 | |
| SCHEMBL23100601 | 0.78 | SMN1; SMN2 (0.43) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190023692-A1 | QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN SCIENCES IRELAND UC (IE) | 2019-01-24 | — | — | US | disclosed |
| US-20190023692-A1 | QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN SCIENCES IRELAND UC (IE) | 2019-01-24 | — | — | US | disclosed |
| US-10081618-B2 | Quinoxalinones and dihydroquinoxalinones as respiratory syncytial virus ativiral agents | JANSSEN SCIENCES IRELAND UC (IE) | 2018-09-25 | — | — | US | disclosed |
| US-20170260166-A1 | QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ATIVIRAL AGENTS | JANSSEN INFECTIOUS DISEASES BVBA (BE) | 2017-09-14 | — | — | US | disclosed |
| US-20170260166-A1 | QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ATIVIRAL AGENTS | JANSSEN INFECTIOUS DISEASES BVBA (BE) | 2017-09-14 | — | — | US | disclosed |
| US-20170260166-A1 | QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ATIVIRAL AGENTS | JANSSEN INFECTIOUS DISEASES BVBA (BE) | 2017-09-14 | — | — | US | disclosed |
| EP-2948444-B1 | QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN SCIENCES IRELAND UC (IE) | 2016-12-07 | — | — | EP | disclosed |
| EP-2948444-B1 | QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN SCIENCES IRELAND UC (IE) | 2016-12-07 | — | — | EP | disclosed |
| WO-2014114776-A1 | QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN R&D IRELAND (IE) | 2014-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190023692-A1 | QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | SQOR, SDHA, DHX15 | AGTR1 505/4885AGTR2 1580/4885TBXA2R 2460/4885 |
| US-20170260166-A1 | QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ATIVIRAL AGENTS | ATIC, DHX15, SQOR | AGTR1 146/4885AGTR2 489/4885TBXA2R 2220/4885 |
| US-10081618-B2 | Quinoxalinones and dihydroquinoxalinones as respiratory syncytial virus ativiral agents | ATIC, DHX15, SQOR | AGTR1 146/4885AGTR2 489/4885TBXA2R 2220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.