Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.49 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15933683 | 0.87 | GPR119 (0.52) | GPR119EGLN2PGGT1BCETPESR2 | |
| SCHEMBL15933677 | 0.86 | GPR119 (0.53) | GPR119EGLN2JAK2JAK1 | |
| SCHEMBL20140942 | 0.85 | CKS1B (0.49) | GPR119JAK2JAK3HDAC4ESR2 | |
| SCHEMBL15933697 | 0.84 | GPR119 (0.47) | GPR119HDAC4ESR2 | |
| SCHEMBL31612680 | 0.84 | HDAC4 (0.48) | GPR119HDAC4ESR2 | |
| SCHEMBL24689567 | 0.83 | NR1H2 (0.43) | GPR119HDAC4ESR2 | |
| SCHEMBL15933643 | 0.80 | GPR119 (0.45) | GPR119CSNK1DCSNK1EHDAC4ESR2 | |
| SCHEMBL15933477 | 0.80 | HDAC4 (0.40) | GPR119JAK2HDAC4JAK1ESR2 | |
| SCHEMBL25431827 | 0.79 | GPR119 (0.43) | GPR119ESR2 | |
| SCHEMBL17984905 | 0.79 | ESR2 (0.40) | CSNK1EJAK2HDAC4JAK1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014117318-A1 | NOVEL TRIAZOLE ANTIFUNGAL COMPOUNDS, AND PHARMACEUTICAL COMPOSITION, PREPARATION METHOD, AND APPLICATION THEREOF | 中国科学院上海药物研究所 (CN) | 2014-08-07 | — | — | WO | disclosed |