SCHEMBL15935552

SCHEMBL15935552

CC(C)(C)c1ccc2c(c1)CC1(C2)OC(=O)Cc2ncncc21

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 1/20 0.30
AVPR1A P37288 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15935556 0.83 AVPR1A (0.40) AVPR1A
SCHEMBL13015185 0.80 DGAT1 (0.30) DGAT1AVPR1A
SCHEMBL15935550 0.79 AVPR1A (0.33) AVPR1A
SCHEMBL13015169 0.71 SIGMAR1 (0.32)
SCHEMBL13015182 0.71 CALCRL (0.38)
SCHEMBL13015184 0.67 KCNH2 (0.39) AVPR1A
SCHEMBL13015186 0.65 ADRA2A (0.33) AVPR1A
SCHEMBL15935910 0.64 AVPR1A (0.36) AVPR1A
SCHEMBL15935557 0.62 CALCRL (0.33)
SCHEMBL26042425 0.61 ALDH1A1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8796260-B2 Imidazobenzazepine CGRP receptor antagonists MERCK SHARP & DOHME CORP. (US) 2014-08-05 US disclosed