Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 3/20 | 0.70 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.70 |
| ▸ | DHODH | Q02127 | 2/20 | 0.52 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.51 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.51 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.51 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.51 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.51 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.51 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | XDH | P47989 | 1/20 | 0.48 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.47 |
| ▸ | RPA1 | P27694 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6508314 | 0.87 | AKR1C2 (0.70) | AKR1C2AKR1C1DHODHMCL1XDH | |
| SCHEMBL28113573 | 0.85 | AKR1C2 (0.56) | AKR1C2AKR1C1DHODHERCC5FEN1 | |
| SCHEMBL122520 | 0.84 | ACMSD (0.63) | AKR1C2AKR1C1GRIK1GRIA1GRIA2 | |
| SCHEMBL2771204 | 0.84 | ALDH1A1 (0.68) | AKR1C2AKR1C1GRIK1GRIA1GRIA2 | |
| SCHEMBL15936129 | 0.83 | ALDH1A1 (0.63) | AKR1C2AKR1C1GRIK1GRIA1GRIA2 | |
| SCHEMBL787129 | 0.83 | AKR1C2 (0.54) | AKR1C2AKR1C1ALDH1A1ERCC5FEN1 | |
| SCHEMBL31312218 | 0.81 | RXRA (0.62) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL9850077 | 0.81 | ACMSD (0.72) | AKR1C2AKR1C1DHODHMCL1ACMSD | |
| SCHEMBL2562897 | 0.81 | EIF4E (0.56) | AKR1C2AKR1C1GRIK1GRIA1GRIA2 | |
| SCHEMBL14783994 | 0.80 | DCLRE1B (0.57) | AKR1C2AKR1C1DHODHGRIK1GRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025006553-A1 | METABOTROPIC GLUTAMATE RECEPTOR POSITIVE ALLOSTERIC MODULATORS AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2025-01-02 | — | — | WO | disclosed |
| US-8748632-B2 | Positive allosteric modulators of group II mGluRs | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2014-06-10 | — | — | US | disclosed |
| US-20120071503-A1 | POSITIVE ALLOSTERIC MODULATORS OF GROUP II MGLURS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071503-A1 | POSITIVE ALLOSTERIC MODULATORS OF GROUP II MGLURS | GRM2, GRM1, GRIN2C | AKR1C2 4832/4885AKR1C1 4866/4885DHODH 4758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.