Sugi Predict

Sugi Predict / Compounds / SCHEMBL15936883

SCHEMBL15936883

SCHEMBL15936883

COC(=O)[C@H](CO[Si](C)(C)C(C)(C)C)NC(=O)OCc1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ KYNU Q16719 1/20 0.54
▸ ALDH1A1 P00352 1/20 0.52
▸ ALOX15 P16050 1/20 0.52
▸ CTSK P43235 7/20 0.51
▸ CTSS P25774 6/20 0.50
▸ CTSL P07711 5/20 0.50
▸ CTSB P07858 3/20 0.50
▸ ATM Q13315 1/20 0.50
▸ SYK P43405 1/20 0.48
▸ ITGB3 P05106 2/20 0.48
▸ ITGA2B P08514 2/20 0.48
▸ CAPN1 P07384 1/20 0.47
▸ TRPM8 Q7Z2W7 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1199068 1.00 KYNU (0.54) KYNUALDH1A1ALOX15CTSKCTSS
SCHEMBL1199066 1.00 KYNU (0.54) KYNUALDH1A1ALOX15CTSKCTSS
SCHEMBL1199787 0.92 ITGB3 (0.53) KYNUALDH1A1ALOX15CTSKCTSS
SCHEMBL7513292 0.92 ITGB3 (0.53) KYNUALDH1A1ALOX15CTSKCTSS
SCHEMBL1199790 0.92 ITGB3 (0.53) KYNUALDH1A1ALOX15CTSKCTSS
SCHEMBL30801699 0.89 CTSL (0.49) KYNUALDH1A1ALOX15CTSKCTSS
SCHEMBL2701065 0.88 KYNU (0.52) KYNUALDH1A1ALOX15CTSKCTSS
SCHEMBL19694732 0.88 KYNU (0.52) KYNUALDH1A1ALOX15CTSKCTSS
SCHEMBL2701068 0.88 KYNU (0.52) KYNUALDH1A1ALOX15CTSKCTSS
SCHEMBL13057155 0.87 CTSK (0.49) ALDH1A1ALOX15CTSKCTSSCTSL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4199925-B1 CYCLOPENTAPYRROLE OREXIN RECEPTOR AGONISTS MERCK SHARP & DOHME LLC (US) 2026-05-20 — — EP disclosed
US-12497362-B2 Cyclopentapyrrole orexin receptor agonists MERCK SHARP & DOHME LLC (US) 2025-12-16 — — US disclosed
EP-4335512-A2 CHROMENOPYRIDINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS HiberCell, Inc. (US) 2024-03-13 — — EP disclosed
US-20230365533-A1 BICYCLOHEPTANE PYRROLIDINE OREXIN RECEPTOR AGONISTS MERCK SHARP & DOHME LLC (US) 2023-11-16 — — US disclosed
EP-3728217-B1 CHROMENOPYRIDINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS HIBERCELL INC (US) 2023-11-15 — — EP disclosed
US-20230257348-A1 CYCLOPENTAPYRROLE OREXIN RECEPTOR AGONISTS MERCK SHARP & DOHME LLC (US) 2023-08-17 — — US disclosed
EP-4199925-A1 CYCLOPENTAPYRROLE OREXIN RECEPTOR AGONISTS Merck Sharp & Dohme LLC (US) 2023-06-28 — — EP disclosed
EP-4200295-A1 BICYCLOHEPTANE PYRROLIDINE OREXIN RECEPTOR AGONISTS Merck Sharp & Dohme LLC (US) 2023-06-28 — — EP disclosed
US-11680060-B2 Bicycloheptane pyrrolidine orexin receptor agonists MERCK SHARP & DOHME LLC (US) 2023-06-20 — — US disclosed
CN-116249697-A Bicycloheptane pyrrolidine orexin receptor agonists 默沙东有限责任公司 2023-06-09 — — CN disclosed
US-20180215767-A1 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF NAUREX, INC. 2018-08-02 — — US disclosed
US-20180179218-A1 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF NAUREX, INC. 2018-06-28 — — US disclosed
US-20180179218-A1 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF NAUREX, INC. 2018-06-28 — — US disclosed
CN-105408336-B Spiro-lactam NMDA receptor modulators and uses thereof 阿普廷伊克斯股份有限公司 2018-06-26 — — CN disclosed
US-9828384-B2 Spiro-lactam NMDA receptor modulators and uses thereof APTINYX INC. (US) 2017-11-28 — — US disclosed
US-9828384-B2 Spiro-lactam NMDA receptor modulators and uses thereof APTINYX INC. (US) 2017-11-28 — — US disclosed
CN-105408336-A Spiro-lactam NMDA receptor modulators and uses thereof APTINYX INC 2016-03-16 — — CN disclosed
US-20150368252-A1 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF NAUREX, INC. (US) 2015-12-24 — — US disclosed
US-20150368252-A1 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF NAUREX, INC. (US) 2015-12-24 — — US disclosed
WO-2014120784-A1 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF NAUREX, INC. (US) 2014-08-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12497362-B2 Cyclopentapyrrole orexin receptor agonists HCRTR2, HCRTR1, NPY1R KYNU 462/4885ALDH1A1 2208/4885ALOX15 899/4885
US-20230365533-A1 BICYCLOHEPTANE PYRROLIDINE OREXIN RECEPTOR AGONISTS HCRTR1, HCRTR2, CRHR1 KYNU 266/4885ALDH1A1 1238/4885ALOX15 852/4885
US-20180179218-A1 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF GRIN1, GRIN2A, GRIN3A KYNU 184/4885ALDH1A1 2288/4885ALOX15 3719/4885
US-11680060-B2 Bicycloheptane pyrrolidine orexin receptor agonists HCRTR1, HCRTR2, CRHR1 KYNU 279/4885ALDH1A1 1885/4885ALOX15 988/4885
US-20180215767-A1 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF GRIN1, GRIN2A, GRIN3A KYNU 184/4885ALDH1A1 2288/4885ALOX15 3719/4885
US-20150368252-A1 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF GRIN1, GRIN2A, GRIN2B KYNU 934/4885ALDH1A1 2911/4885ALOX15 4009/4885
US-20230257348-A1 CYCLOPENTAPYRROLE OREXIN RECEPTOR AGONISTS HCRTR2, HCRTR1, NPY1R KYNU 462/4885ALDH1A1 2208/4885ALOX15 899/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.