Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 1/20 | 0.67 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 7/20 | 0.66 |
| ▸ | RAB9A | P51151 | 7/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.61 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15946363 | 0.88 | SIRT1 (0.64) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL408310 | 0.87 | CYP2C9 (0.67) | NPC1RAB9APOLBSMN1; SMN2LMNA | |
| SCHEMBL13701743 | 0.87 | HDAC1 (0.66) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL23139020 | 0.86 | NPC1 (0.55) | CACNA1BAPBA1NPC1RAB9AKMT2A | |
| SCHEMBL21282783 | 0.86 | HDAC3 (0.73) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL15946364 | 0.85 | ALDH1A1 (0.63) | NPC1RAB9AKMT2AMEN1POLB | |
| Bromide SCHEMBL6851253 | 0.85 | CYP2C9 (0.65) | NPC1RAB9APOLBSMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL22076570 | 0.85 | CYP2C9 (0.65) | NPC1RAB9APOLBSMN1; SMN2LMNA | |
| SCHEMBL29201540 | 0.85 | CYP2C9 (0.65) | NPC1RAB9APOLBSMN1; SMN2LMNA | |
| Fluoride SCHEMBL2310518 | 0.85 | CYP2C9 (0.65) | NPC1RAB9APOLBSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9464064-B2 | HCV helicase inhibitors and methods of use thereof | UNIVERSITY OF KANSAS (US) | 2016-10-11 | — | — | US | disclosed |
| US-20140227225-A1 | HCV Helicase Inhibitors and Methods of Use Thereof | UWM RESEARCH FOUNDATION, INC. (US) | 2014-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140227225-A1 | HCV Helicase Inhibitors and Methods of Use Thereof | DHX15, DDX5, DHX35 | CACNA1B 4627/4885APBA1 2340/4885NPC1 2518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.