SCHEMBL15947754

SCHEMBL15947754

O=C1c2ccccc2C(=O)N1CC[C@@H]1CO1

nearest known ligand 0.55

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.55
CYP1A2 P05177 2/20 0.51
CYP2C9 P11712 2/20 0.51
CYP2C19 P33261 2/20 0.51
GLS O94925 1/20 0.50
NPSR1 Q6W5P4 1/20 0.46
MIF P14174 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
NPC1 O15118 1/20 0.45
CASP3 P42574 1/20 0.45
RAB9A P51151 1/20 0.45
SENP8 Q96LD8 1/20 0.45
SENP7 Q9BQF6 1/20 0.45
SENP6 Q9GZR1 1/20 0.45
TP53 P04637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15945774 1.00 ACHE (0.55) ACHECYP1A2CYP2C9CYP2C19GLS
SCHEMBL31348131 1.00 ACHE (0.55) ACHECYP1A2CYP2C9CYP2C19GLS
SCHEMBL1905981 1.00 ACHE (0.55) ACHECYP1A2CYP2C9CYP2C19GLS
SCHEMBL571018 0.90 CYP1A2 (0.56) ACHECYP1A2CYP2C9CYP2C19MIF
SCHEMBL8061487 0.88 TDP1 (0.51) CYP1A2CYP2C9CYP2C19
SCHEMBL17983202 0.87 ACHE (0.43) ACHECYP1A2CYP2C9CYP2C19GLS
SCHEMBL8070914 0.87 TDP1 (0.54) CYP1A2CYP2C9CYP2C19
SCHEMBL8071862 0.87 TDP1 (0.54) CYP1A2CYP2C9CYP2C19
SCHEMBL4495927 0.85 HEXA (0.58) CYP1A2NPSR1SMN1; SMN2RAB9A
SCHEMBL38819 0.81 CYP2C9 (0.68) ACHECYP1A2CYP2C9CYP2C19GLS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3848351-B1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF US HEALTH (US) 2025-01-15 EP disclosed
US-20240408084-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS AND USES THEREOF THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-12-12 US disclosed
US-12162861-B2 Dopamine D3 receptor selective antagonists/partial agonists; method of making; and use thereof THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-12-10 US disclosed
US-12097196-B2 Dopamine D3 receptor selective antagonists/partial agonists and uses thereof THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-09-24 US disclosed
US-20220265643-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS AND USES THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2022-08-25 US disclosed
US-20220185798-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2022-06-16 US disclosed
US-20220185798-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2022-06-16 US disclosed
US-11337971-B2 Dopamine D3 receptor selective antagonists/partial agonists and uses thereof THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2022-05-24 US disclosed
US-11337971-B2 Dopamine D3 receptor selective antagonists/partial agonists and uses thereof THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2022-05-24 US disclosed
US-11299476-B2 Dopamine D3 receptor selective antagonists/partial agonists; method of making; and use thereof THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2022-04-12 US disclosed
EP-3849963-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS AND USES THEREOF The United States of America, as Represented By the Secretary, Department of Health and Human Services (US) 2021-07-21 EP disclosed
EP-3848351-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF The United States of America, as represented by The Secretary, Department of Health and Human Services (US) 2021-07-14 EP disclosed
EP-3429993-B1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF US HEALTH (US) 2021-05-26 EP disclosed
US-20200291000-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2020-09-17 US disclosed
US-20200291000-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2020-09-17 US disclosed
WO-2020055725-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS AND USES THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2020-03-19 WO disclosed
EP-3429993-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF The U.S.A. As Represented By The Secretary, Department Of Health And Human Services (US) 2019-01-23 EP disclosed
WO-2017160552-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2017-09-21 WO disclosed
US-9290503-B2 Tricyclic compound derivatives useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders CHEMBRIDGE CORPORATION (US) 2016-03-22 US disclosed
US-20140228350-A1 TRICYCLIC COMPOUND DERIVATIVES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY DISORDERS AND IMMUNOMODULATORY DISORDERS CHEMBRIDGE CORPORATION (US) 2014-08-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140228350-A1 TRICYCLIC COMPOUND DERIVATIVES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY DISORDERS AND IMMUNOMODULATORY DISORDERS MALT1, TPMT, TSLP ACHE 3905/4885CYP1A2 1089/4885CYP2C9 1806/4885
US-20220185798-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF DRD3, DRD2, SLC6A3 ACHE 1090/4885CYP1A2 1308/4885CYP2C9 2366/4885
US-12162861-B2 Dopamine D3 receptor selective antagonists/partial agonists; method of making; and use thereof DRD3, DRD2, SLC6A3 ACHE 1090/4885CYP1A2 1308/4885CYP2C9 2366/4885
US-20200291000-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF DRD3, DRD2, SLC6A3 ACHE 1090/4885CYP1A2 1308/4885CYP2C9 2366/4885
US-12097196-B2 Dopamine D3 receptor selective antagonists/partial agonists and uses thereof OPRD1, OPRK1, DRD3 ACHE 374/4885CYP1A2 455/4885CYP2C9 930/4885
US-11299476-B2 Dopamine D3 receptor selective antagonists/partial agonists; method of making; and use thereof DRD3, DRD2, SLC6A3 ACHE 1090/4885CYP1A2 1308/4885CYP2C9 2366/4885
US-20240408084-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS AND USES THEREOF DRD3, OPRD1, DRD2 ACHE 1054/4885CYP1A2 619/4885CYP2C9 1625/4885
US-20220265643-A1 DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS AND USES THEREOF OPRD1, OPRK1, DRD3 ACHE 374/4885CYP1A2 455/4885CYP2C9 930/4885
US-11337971-B2 Dopamine D3 receptor selective antagonists/partial agonists and uses thereof OPRD1, OPRK1, DRD3 ACHE 374/4885CYP1A2 455/4885CYP2C9 930/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.