Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 5/20 | 0.51 |
| ▸ | RNASEL | Q05823 | 5/20 | 0.51 |
| ▸ | P2RY11 | Q96G91 | 2/20 | 0.49 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.49 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.49 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.49 |
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | FBP1 | P09467 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.49 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.49 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.49 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7708744 | 0.85 | ADORA3 (0.55) | ADORA1RNASELP2RY11DNPH1PRKAB2 | |
| SCHEMBL7708739 | 0.85 | ADORA3 (0.55) | ADORA1RNASELP2RY11DNPH1PRKAB2 | |
| SCHEMBL2534140 | 0.81 | EHMT1 (0.70) | ADORA1P2RY11DNPH1PRKAB2TRPM2 | |
| SCHEMBL1582614 | 0.80 | EHMT1 (0.62) | ADORA1RNASELADORA3EHMT1 | |
| SCHEMBL5221238 | 0.79 | ADORA1 (0.53) | ADORA1RNASELSMN1; SMN2ADORA3ADORA2A | |
| SCHEMBL18349673 | 0.78 | ADORA1 (0.49) | ADORA1RNASELP2RY11DNPH1PRKAB2 | |
| SCHEMBL7906331 | 0.78 | ADORA1 (0.54) | ADORA1RNASELP2RY11DNPH1PRKAB2 | |
| SCHEMBL7906337 | 0.77 | HSPA5 (0.62) | ADORA1RNASELADORA3 | |
| SCHEMBL7902968 | 0.77 | ADORA1 (0.53) | ADORA1RNASELP2RY11DNPH1PRKAB2 | |
| SCHEMBL18349664 | 0.77 | ADORA1 (0.49) | ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200276222-A1 | 2'-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS | IONIS PHARMACEUTICALS, INC. (US) | 2020-09-03 | — | — | US | disclosed |
| US-10478449-B2 | 2′-methoxy substituted oligomeric compounds and compositions for use in gene modulations | IONIS PHARMACEUTICALS, INC. (US) | 2019-11-19 | — | — | US | disclosed |
| US-20180200282-A1 | 2'-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS | IONIS PHARMACEUTICALS, INC. (US) | 2018-07-19 | — | — | US | disclosed |
| US-20180104272-A1 | 2'-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS | IONIS PHARMACEUTICALS, INC. (US) | 2018-04-19 | — | — | US | disclosed |
| US-20180104271-A1 | 2'-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS | IONIS PHARMACEUTICALS, INC. (US) | 2018-04-19 | — | — | US | disclosed |
| US-9943539-B1 | 2′-methoxy substituted oligomeric compounds and compositions for use in gene modulations | IONIS PHARMACEUTICALS, INC. (US) | 2018-04-17 | — | — | US | disclosed |
| US-9943538-B1 | 2′-methoxy substituted oligomeric compounds and compositions for use in gene modulations | IONIS PHARMACEUTICALS, INC. (US) | 2018-04-17 | — | — | US | disclosed |
| US-20180028555-A1 | 2'-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS | IONIS PHARMACEUTICALS, INC. (US) | 2018-02-01 | — | — | US | disclosed |
| US-9827263-B2 | 2′-methoxy substituted oligomeric compounds and compositions for use in gene modulations | IONIS PHARMACEUTICALS, INC. (US) | 2017-11-28 | — | — | US | disclosed |
| US-20150366894-A1 | 2'-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS | ISIS PHARMACEUTICALS, INC. (US) | 2015-12-24 | — | — | US | disclosed |
| US-20040203024-A1 | Modified oligonucleotides for use in RNA interference | ISIS PHARMACEUTICALS, INC. | 2004-10-14 | — | — | US | disclosed |
| US-20040171033-A1 | 2'-substituted oligomeric compounds and compositions for use in gene modulations | ISIS PHARMACEUTICALS, INC. | 2004-09-02 | — | — | US | disclosed |
| US-20040171029-A1 | 2'-Fluoro substituted oligomeric compounds and compositions for use in gene modulations | ISIS PHARMACEUTICALS, INC. | 2004-09-02 | — | — | US | disclosed |
| US-20040161777-A1 | Nucleotide sequences comprising terminal caps and inverted 3'-3' linkage for use in gene expression inhibition and preventing disease | ISIS PHARMACEUTICALS, INC. | 2004-08-19 | — | — | US | disclosed |
| WO-2004044132-A2 | MODIFIED OLIGONUCLEOTIDES FOR USE IN RNA INTERFERENCE | ISIS PHARMACEUTICALS, INC. (US) | 2004-05-27 | — | — | WO | disclosed |
| WO-2004044133-A2 | MODIFIED OLIGONUCLEOTIDES FOR USE IN RNA INTERFERENCE | ISIS PHARMACEUTICALS, INC. (US) | 2004-05-27 | — | — | WO | disclosed |
| WO-2004043977-A2 | 2’-FLUORO SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS | ISIS PHARMACEUTICALS, INC. (US) | 2004-05-27 | — | — | WO | disclosed |
| WO-2004043978-A2 | 2'-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS | ISIS PHARMACEUTICALS, INC. (US) | 2004-05-27 | — | — | WO | disclosed |
| WO-2004044140-A2 | 2’-SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS | ISIS PHARMACETICALS, INC. (US) | 2004-05-27 | — | — | WO | disclosed |
| US-5872232-A | 2'-O-modified oligonucleotides | ISIS PHARMACEUTICALS INC. (US) | 1999-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040203024-A1 | Modified oligonucleotides for use in RNA interference | NSUN2, NSUN3, RNGTT | ADORA1 3386/4885RNASEL 5/4885P2RY11 4378/4885 |
| US-20200276222-A1 | 2'-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS | NSUN2, SNRPE, RBM3 | ADORA1 4428/4885RNASEL 87/4885P2RY11 4844/4885 |
| US-20180200282-A1 | 2'-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS | NSUN2, SNRPE, RBM3 | ADORA1 4428/4885RNASEL 87/4885P2RY11 4844/4885 |
| US-10478449-B2 | 2′-methoxy substituted oligomeric compounds and compositions for use in gene modulations | NSUN2, SNRPE, RBM3 | ADORA1 4432/4885RNASEL 86/4885P2RY11 4844/4885 |
| US-20040171029-A1 | 2'-Fluoro substituted oligomeric compounds and compositions for use in gene modulations | NSUN2, HNRNPC, AGO2 | ADORA1 3908/4885RNASEL 59/4885P2RY11 4759/4885 |
| US-20150366894-A1 | 2'-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS | NSUN2, SNRPE, RBM3 | ADORA1 4428/4885RNASEL 87/4885P2RY11 4844/4885 |
| US-20180028555-A1 | 2'-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS | NSUN2, SNRPE, RBM3 | ADORA1 4428/4885RNASEL 87/4885P2RY11 4844/4885 |
| US-20040171033-A1 | 2'-substituted oligomeric compounds and compositions for use in gene modulations | NSUN2, HNRNPC, SNRPE | ADORA1 4211/4885RNASEL 81/4885P2RY11 4822/4885 |
| US-20180104272-A1 | 2'-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS | NSUN2, SNRPE, RBM3 | ADORA1 4428/4885RNASEL 87/4885P2RY11 4844/4885 |
| US-20040161777-A1 | Nucleotide sequences comprising terminal caps and inverted 3'-3' linkage for use in gene expression inhibition and preventing disease | RNGTT, RNMT, NUDT21 | ADORA1 4612/4885RNASEL 432/4885P2RY11 4515/4885 |
| US-20180104271-A1 | 2'-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS | NSUN2, SNRPE, RBM3 | ADORA1 4428/4885RNASEL 87/4885P2RY11 4844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.