Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 2/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | HTR5A | P47898 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 2/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | CASP9 | P55211 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.31 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL116597 | 0.87 | ALDH1A1 (0.37) | PDK2TP53ALDH1A1DDB1CRBN | |
| SCHEMBL15966870 | 0.82 | AHR (0.62) | AHRSMYD3HTR5AGRIA1CACNG8 | |
| SCHEMBL15966884 | 0.81 | HTR5A (0.40) | AHRSMYD3HTR5ATP53ALDH1A1 | |
| SCHEMBL261018 | 0.79 | AHR (0.61) | AHRSMYD3SRD5A1HTR5AOPRL1 | |
| SCHEMBL15967351 | 0.78 | GRIA1 (0.33) | GRIA1CACNG8TDP2 | |
| SCHEMBL10952280 | 0.71 | ALDH1A1 (0.37) | ALDH1A1 | |
| SCHEMBL11368672 | 0.70 | DAO (0.40) | PDK2ALDH1A1DDB1CRBN | |
| SCHEMBL117727 | 0.69 | CACNB4 (0.40) | AHRCACNG8ALDH1A1 | |
| SCHEMBL11094086 | 0.68 | HTR1A (0.34) | HTR5AALDH1A1 | |
| SCHEMBL1321330 | 0.67 | HTR2C (0.46) | HTR5AALDH1A1DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569283-B1 | METHOD FOR PRODUCING SUBSTITUTED 1,3-DIHYDRO-2H-INDOL-2-ONES | BAYER IP GMBH (DE) | 2014-08-27 | — | — | EP | disclosed |